On this page, we present all of the funds holding PTGX from our database of 13F filers, detailed in the table below. The first column indicates the name of each of the funds holding PTGX, with a link to that fund's top holdings. The next columns indicate the amount of PTGX stock held by each of the funds holding PTGX, followed by the PTGX position size held by the fund, and lastly the date of the quarterly filing period the data represents. In total, we count 159 funds holding PTGX within the last two filing periods in our coverage universe of 13F filers, with the largest position size having been reported by BVF Inc. IL. For more details on the positions held by BVF Inc. IL (or by any of the other funds holding PTGX), click the fund name in the "Holder" column of the funds-holding-PTGX table below.

Holder	Amount	Position Size ($ in 1000's)	As of
BVF Inc. IL	5,744,848	$131,729	12/31/2023
PTGX	5,744,848	$131,729	12/31/2023
Farallon Capital Management LLC	5,734,430	$131,490	12/31/2023
PTGX	5,734,430	$131,490	12/31/2023
BlackRock Inc.	5,543,902	$127,122	12/31/2023
PTGX	5,543,902	$127,122	12/31/2023
RTW Investments LP	5,315,514	$121,885	12/31/2023
PTGX	5,315,514	$121,885	12/31/2023
Vanguard Group Inc.	3,153,916	$72,319	12/31/2023
PTGX	3,153,916	$72,319	12/31/2023
State Street Corp	2,729,929	$62,597	12/31/2023
PTGX	2,729,929	$62,597	12/31/2023
Point72 Asset Management L.P.	2,613,453	$59,926	12/31/2023
PTGX	2,613,453	$59,926	12/31/2023
Johnson & Johnson	2,449,183	$56,160	12/31/2023
PTGX	2,449,183	$56,160	12/31/2023
Kynam Capital Management LP	2,004,875	$45,972	12/31/2023
PTGX	2,004,875	$45,972	12/31/2023
Adage Capital Partners GP L.L.C.	1,291,701	$29,619	12/31/2023
PTGX	1,291,701	$29,619	12/31/2023
Jefferies Financial Group Inc.	1,270,561	$29,134	12/31/2023
PTGX	1,270,561	$29,134	12/31/2023
Geode Capital Management LLC	1,248,284	$28,626	12/31/2023
PTGX	1,248,284	$28,626	12/31/2023
Morgan Stanley	1,191,837	$27,329	12/31/2023
PTGX	1,191,837	$27,329	12/31/2023
Deutsche Bank AG	910,012	$20,867	12/31/2023
PTGX	910,012	$20,867	12/31/2023
Price T Rowe Associates Inc. MD	823,740	$18,889	12/31/2023
PTGX	823,740	$18,889	12/31/2023
Dimensional Fund Advisors LP	816,537	$18,724	12/31/2023
PTGX	816,537	$18,724	12/31/2023
683 Capital Management LLC	715,000	$16,395	12/31/2023
PTGX	715,000	$16,395	12/31/2023
Northern Trust Corp	550,139	$12,615	12/31/2023
PTGX	550,139	$12,615	12/31/2023
Eversept Partners LP	538,074	$12,338	12/31/2023
PTGX	538,074	$12,338	12/31/2023
Candriam Luxembourg S.C.A.	537,000	$12,314	12/31/2023
PTGX	537,000	$12,314	12/31/2023
Goldman Sachs Group Inc.	515,220	$11,814	12/31/2023
PTGX	515,220	$11,814	12/31/2023
StemPoint Capital LP	513,681	$11,779	12/31/2023
PTGX	513,681	$11,779	12/31/2023
FMR LLC	465,952	$10,684	12/31/2023
PTGX	465,952	$10,684	12/31/2023
Sio Capital Management LLC	460,044	$10,549	12/31/2023
PTGX	460,044	$10,549	12/31/2023
Charles Schwab Investment Management Inc.	455,321	$10,441	12/31/2023
PTGX	455,321	$10,441	12/31/2023
Mangrove Partners	439,314	$10,073	12/31/2023
PTGX	439,314	$10,073	12/31/2023
JPMorgan Chase & Co.	411,046	$9,425	12/31/2023
PTGX	411,046	$9,425	12/31/2023
Gratus Capital LLC	397,571	$9,116	12/31/2023
PTGX	397,571	$9,116	12/31/2023
Perceptive Advisors LLC	383,260	$8,788	12/31/2023
PTGX	383,260	$8,788	12/31/2023
Superstring Capital Management LP	379,143	$8,694	12/31/2023
PTGX	379,143	$8,694	12/31/2023
Citadel Advisors LLC		$7,693	12/31/2023
Call	342,600	$7,856	12/31/2023
Put	55,000	$1,261	12/31/2023
PTGX	47,864	$1,098	12/31/2023
Ikarian Capital LLC	319,000	$7,315	12/31/2023
PTGX	319,000	$7,315	12/31/2023
Nuveen Asset Management LLC	305,419	$7,003	12/31/2023
PTGX	305,419	$7,003	12/31/2023
Kennedy Capital Management Inc.	304,790	$6,989	12/31/2023
PTGX	304,790	$6,989	12/31/2023
UBS Asset Management Americas Inc.	289,079	$6,629	12/31/2023
PTGX	289,079	$6,629	12/31/2023
Deep Track Capital LP	275,201	$6,310	12/31/2023
PTGX	275,201	$6,310	12/31/2023
Checkpoint Capital L.P.	266,856	$6,119	12/31/2023
PTGX	266,856	$6,119	12/31/2023
Susquehanna International Group LLP		$6,065	12/31/2023
Call	188,400	$4,320	12/31/2023
PTGX	109,683	$2,515	12/31/2023
Put	33,600	$770	12/31/2023
Two Sigma Advisers LP	222,000	$5,090	12/31/2023
PTGX	222,000	$5,090	12/31/2023
Renaissance Technologies LLC	213,967	$4,906	12/31/2023
PTGX	213,967	$4,906	12/31/2023
Bank of New York Mellon Corp	203,177	$4,659	12/31/2023
PTGX	203,177	$4,659	12/31/2023
ADAR1 Capital Management LLC	200,859	$4,606	12/31/2023
PTGX	200,859	$4,606	12/31/2023
Driehaus Capital Management LLC	198,689	$4,556	12/31/2023
PTGX	198,689	$4,556	12/31/2023
Walleye Capital LLC	185,426	$4,252	12/31/2023
PTGX	185,426	$4,252	12/31/2023
Silvercrest Asset Management Group LLC	180,496	$4,139	12/31/2023
PTGX	180,496	$4,139	12/31/2023
Rafferty Asset Management LLC	167,795	$3,848	12/31/2023
PTGX	167,795	$3,848	12/31/2023
Two Sigma Investments LP	158,843	$3,642	12/31/2023
PTGX	158,843	$3,642	12/31/2023
Bank of America Corp DE	153,409	$3,518	12/31/2023
PTGX	153,409	$3,518	12/31/2023
UBS Group AG	150,867	$3,459	12/31/2023
PTGX	150,867	$3,459	12/31/2023
Millennium Management LLC	149,163	$3,420	12/31/2023
PTGX	149,163	$3,420	12/31/2023
Barclays PLC	148,974	$3,415	12/31/2023
PTGX	148,974	$3,415	12/31/2023
Marshall Wace LLP	142,470	$3,267	12/31/2023
PTGX	142,470	$3,267	12/31/2023
Jacobs Levy Equity Management Inc.	129,011	$2,958	12/31/2023
PTGX	129,011	$2,958	12/31/2023
Ghost Tree Capital LLC	125,000	$2,866	12/31/2023
PTGX	125,000	$2,866	12/31/2023
Hsbc Holdings PLC	119,334	$2,739	12/31/2023
PTGX	119,334	$2,739	12/31/2023
Opaleye Management Inc.	112,700	$2,584	12/31/2023
PTGX	112,700	$2,584	12/31/2023
Artia Global Partners LP	112,340	$2,576	12/31/2023
PTGX	112,340	$2,576	12/31/2023
TD Asset Management Inc.	110,800	$2,541	12/31/2023
PTGX	110,800	$2,541	12/31/2023
Connor Clark & Lunn Investment Management Ltd.	107,542	$2,466	12/31/2023
PTGX	107,542	$2,466	12/31/2023
UBS Oconnor LLC	106,154	$2,434	12/31/2023
PTGX	106,154	$2,434	12/31/2023
Group One Trading L.P.		$2,272	12/31/2023
Call	99,100	$2,272	12/31/2023
Great Lakes Advisors LLC	91,153	$2,090	12/31/2023
PTGX	91,153	$2,090	12/31/2023
Swiss National Bank	90,700	$2,080	12/31/2023
PTGX	90,700	$2,080	12/31/2023
Schonfeld Strategic Advisors LLC	89,113	$2,043	12/31/2023
PTGX	89,113	$2,043	12/31/2023
Alliancebernstein L.P.	85,400	$1,958	12/31/2023
PTGX	85,400	$1,958	12/31/2023
Rhumbline Advisers	83,292	$1,910	12/31/2023
PTGX	83,292	$1,910	12/31/2023
Soleus Capital Management L.P.	83,000	$1,903	12/31/2023
PTGX	83,000	$1,903	12/31/2023
Boothbay Fund Management LLC	80,607	$1,848	12/31/2023
PTGX	80,607	$1,848	12/31/2023
Algert Global LLC	75,760	$1,737	12/31/2023
PTGX	75,760	$1,737	12/31/2023
HRT Financial LP	73,126	$1,676	12/31/2023
PTGX	73,126	$1,676	12/31/2023
Jane Street Group LLC	72,931	$1,672	12/31/2023
PTGX	72,931	$1,672	12/31/2023
Citigroup Inc.	72,703	$1,667	12/31/2023
PTGX	72,703	$1,667	12/31/2023
BNP Paribas Arbitrage SA	71,898	$1,649	12/31/2023
PTGX	71,898	$1,649	12/31/2023
The Manufacturers Life Insurance Company	68,432	$1,569	12/31/2023
PTGX	68,432	$1,569	12/31/2023
Credit Suisse AG	62,517	$1,434	12/31/2023
PTGX	62,517	$1,434	12/31/2023
Moody Aldrich Partners LLC	62,327	$1,429	12/31/2023
PTGX	62,327	$1,429	12/31/2023
Readystate Asset Management LP	57,206	$1,312	12/31/2023
PTGX	57,206	$1,312	12/31/2023
Knott David M Jr	52,368	$1,201	12/31/2023
PTGX	52,368	$1,201	12/31/2023
Balyasny Asset Management LLC	50,503	$1,158	12/31/2023
PTGX	50,503	$1,158	12/31/2023
California State Teachers Retirement System	50,392	$1,155	12/31/2023
PTGX	50,392	$1,155	12/31/2023
Birchview Capital LP	48,000	$1,101	12/31/2023
PTGX	48,000	$1,101	12/31/2023
Invesco Ltd.	45,763	$1,049	12/31/2023
PTGX	45,763	$1,049	12/31/2023
Legal & General Group Plc	45,289	$1,038	12/31/2023
PTGX	45,289	$1,038	12/31/2023
Hennion & Walsh Asset Management Inc.	34,895	$1,010	03/31/2024
PTGX	34,895	$1,010	03/31/2024
Voya Investment Management LLC	43,245	$992	12/31/2023
PTGX	43,245	$992	12/31/2023
Alps Advisors Inc.	40,072	$919	12/31/2023
PTGX	40,072	$919	12/31/2023
State of Wisconsin Investment Board	39,799	$913	12/31/2023
PTGX	39,799	$913	12/31/2023
Los Angeles Capital Management & Equity Research Inc.	30,827	$892	03/31/2024
PTGX	30,827	$892	03/31/2024
American Century Companies Inc.	38,344	$879	12/31/2023
PTGX	38,344	$879	12/31/2023
Sei Investments Co.	37,229	$854	12/31/2023
PTGX	37,229	$854	12/31/2023
Mirae Asset Global Investments Co. Ltd.	31,759	$728	12/31/2023
PTGX	31,759	$728	12/31/2023
Fox Run Management L.L.C.	31,275	$717	12/31/2023
PTGX	31,275	$717	12/31/2023
Bellevue Group AG	30,000	$688	12/31/2023
PTGX	30,000	$688	12/31/2023
AlphaCentric Advisors LLC	30,000	$688	12/31/2023
PTGX	30,000	$688	12/31/2023
Tudor Investment Corp Et Al	28,786	$660	12/31/2023
PTGX	28,786	$660	12/31/2023
MetLife Investment Management LLC	28,596	$656	12/31/2023
PTGX	28,596	$656	12/31/2023
American International Group Inc.	28,390	$651	12/31/2023
PTGX	28,390	$651	12/31/2023
Ensign Peak Advisors Inc	28,400	$651	12/31/2023
PTGX	28,400	$651	12/31/2023
HighVista Strategies LLC	28,359	$650	12/31/2023
PTGX	28,359	$650	12/31/2023
Profund Advisors LLC	27,890	$640	12/31/2023
PTGX	27,890	$640	12/31/2023
Twinbeech Capital LP	24,161	$554	12/31/2023
PTGX	24,161	$554	12/31/2023
New York State Common Retirement Fund	23,103	$530	12/31/2023
PTGX	23,103	$530	12/31/2023
Janus Henderson Group PLC	21,734	$499	12/31/2023
PTGX	21,734	$499	12/31/2023
Schroder Investment Management Group	19,900	$456	12/31/2023
COM	19,900	$456	12/31/2023
GSA Capital Partners LLP	19,788	$454	12/31/2023
PTGX	19,788	$454	12/31/2023
Skandinaviska Enskilda Banken AB publ	18,914	$434	12/31/2023
PTGX	18,914	$434	12/31/2023
Royal Bank of Canada	17,455	$400	12/31/2023
PTGX	17,455	$400	12/31/2023
CWM Advisors LLC	16,782	$385	12/31/2023
PTGX	16,782	$385	12/31/2023
Corton Capital Inc.	16,428	$377	12/31/2023
PTGX	16,428	$377	12/31/2023
State Board of Administration of Florida Retirement System	16,303	$374	12/31/2023
PTGX	16,303	$374	12/31/2023
Wells Fargo & Company MN	16,157	$370	12/31/2023
PTGX	16,157	$370	12/31/2023
DekaBank Deutsche Girozentrale	15,800	$362	12/31/2023
PTGX	15,800	$362	12/31/2023
Nebula Research & Development LLC	15,286	$351	12/31/2023
PTGX	15,286	$351	12/31/2023
Franklin Street Advisors Inc. NC	11,470	$332	03/31/2024
PTGX	11,470	$332	03/31/2024
Principal Financial Group Inc.	14,429	$331	12/31/2023
PTGX	14,429	$331	12/31/2023
ProShare Advisors LLC	13,139	$301	12/31/2023
PTGX	13,139	$301	12/31/2023
Arizona State Retirement System	12,866	$295	12/31/2023
PTGX	12,866	$295	12/31/2023
Bayesian Capital Management LP	12,661	$290	12/31/2023
PTGX	12,661	$290	12/31/2023
Engineers Gate Manager LP	12,522	$287	12/31/2023
PTGX	12,522	$287	12/31/2023
Obermeyer Wood Investment Counsel Lllp	12,066	$277	12/31/2023
PTGX	12,066	$277	12/31/2023
Chartwell Investment Partners LLC	12,098	$277	12/31/2023
PTGX	12,098	$277	12/31/2023
King Wealth	12,000	$275	12/31/2023
PTGX	12,000	$275	12/31/2023
Brevan Howard Capital Management LP	11,806	$271	12/31/2023
PTGX	11,806	$271	12/31/2023
Tower Research Capital LLC TRC	11,759	$270	12/31/2023
PTGX	11,759	$270	12/31/2023
Bridgefront Capital LLC	11,370	$261	12/31/2023
PTGX	11,370	$261	12/31/2023
Cerity Partners LLC	11,265	$258	12/31/2023
PTGX	11,265	$258	12/31/2023
Teacher Retirement System of Texas	10,640	$244	12/31/2023
PTGX	10,640	$244	12/31/2023
Zurcher Kantonalbank Zurich Cantonalbank	10,338	$237	12/31/2023
PTGX	10,338	$237	12/31/2023
AQR Capital Management LLC	9,342	$214	12/31/2023
PTGX	9,342	$214	12/31/2023
Mariner LLC	9,254	$212	12/31/2023
PTGX	9,254	$212	12/31/2023
E Fund Management Co. Ltd.	8,957	$205	12/31/2023
PTGX	8,957	$205	12/31/2023
Aquatic Capital Management LLC	8,700	$199	12/31/2023
PTGX	8,700	$199	12/31/2023
US Bancorp DE	7,167	$164	12/31/2023
PTGX	7,167	$164	12/31/2023
Amalgamated Bank	6,861	$157	12/31/2023
PTGX	6,861	$157	12/31/2023
China Universal Asset Management Co. Ltd.	6,675	$153	12/31/2023
PTGX	6,675	$153	12/31/2023
Ameritas Investment Partners Inc.	5,912	$136	12/31/2023
PTGX	5,912	$136	12/31/2023
Great West Life Assurance Co. Can	5,213	$119	12/31/2023
PTGX	5,213	$119	12/31/2023
Virtus ETF Advisers LLC	4,457	$102	12/31/2023
PTGX	4,457	$102	12/31/2023
EntryPoint Capital LLC	3,696	$85	12/31/2023
PTGX	3,696	$85	12/31/2023
Metropolitan Life Insurance Co NY	3,352	$77	12/31/2023
PTGX	3,352	$77	12/31/2023
Nisa Investment Advisors LLC	2,639	$61	12/31/2023
PTGX	2,639	$61	12/31/2023
Allspring Global Investments Holdings LLC	1,970	$57	03/31/2024
PTGX	1,970	$57	03/31/2024
Strs Ohio	2,400	$55	12/31/2023
PTGX	2,400	$55	12/31/2023
Amundi	2,032	$52	12/31/2023
PTGX	2,032	$52	12/31/2023
Quarry LP	750	$17	12/31/2023
PTGX	750	$17	12/31/2023
Global Retirement Partners LLC	300	$7	12/31/2023
PTGX	300	$7	12/31/2023
Advisor Group Holdings Inc.	281	$6	12/31/2023
PTGX	281	$6	12/31/2023
CWM LLC	175	$5	03/31/2024
PTGX	175	$5	03/31/2024
Comerica Bank	227	$5	12/31/2023
PTGX	227	$5	12/31/2023
Daiwa Securities Group Inc.	163	$4	12/31/2023
PTGX	163	$4	12/31/2023
Truvestments Capital LLC	131	$3	12/31/2023
PTGX	131	$3	12/31/2023
Northwestern Mutual Wealth Management Co.	100	$2	12/31/2023
PTGX	100	$2	12/31/2023
GAMMA Investing LLC	48	$1	03/31/2024
PTGX	48	$1	03/31/2024
Farther Finance Advisors LLC	40	$1	12/31/2023
PTGX	40	$1	12/31/2023
Principal Securities Inc.	6	$0	12/31/2023
PTGX	6	$0	12/31/2023
The PNC Financial Services Group Inc.	5	$0	12/31/2023
PTGX	5	$0	12/31/2023
Proequities Inc.		$0	12/31/2023
Put	0	$0	12/31/2023
Call	0	$0	12/31/2023
PTGX	0	$0	12/31/2023
Gradient Investments LLC	1	$0	12/31/2023
PTGX	1	$0	12/31/2023
Covestor Ltd	5	$0	12/31/2023
PTGX	5	$0	12/31/2023
Simplex Trading LLC	2,834	$-278	12/31/2023
Put	19,300	$442	12/31/2023
Call	4,400	$100	12/31/2023
PTGX	2,834	$64	12/31/2023

See Summary: Institutional Holders of PTGX
See Details: Top 10 Hedge Funds Holding PTGX
Also See: PTGX Insider Buying
Also See: PTGX Holdings Changes

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PTGX — Performance