HoldingsChannel.com
Funds Holding IONS
HolderAmountPosition Size
($ in 1000's)
 As of
FMR LLC20,935,784$1,254,263 09/30/2019
     IONS20,935,784$1,254,263 09/30/2019
Vanguard Group Inc.12,214,475$731,769 09/30/2019
     IONS12,214,475$731,769 09/30/2019
Clearbridge Investments LLC9,290,924$556,619 09/30/2019
     IONS9,290,924$556,619 09/30/2019
Baillie Gifford & Co.8,415,289$504,160 09/30/2019
     IONS8,415,289$504,160 09/30/2019
BlackRock Inc.8,350,799$500,297 09/30/2019
     IONS8,350,799$500,297 09/30/2019
Bellevue Group AG8,321,914$498,566 09/30/2019
     IONS8,321,914$498,566 09/30/2019
Wellington Management Group LLP7,745,339$464,023 09/30/2019
     IONS7,745,339$464,023 09/30/2019
State Street Corp $242,596 09/30/2019
     IONS3,650,783$218,718 09/30/2019
     NOTE 120,890,000$23,878 09/30/2019
Waddell & Reed Financial Inc.3,180,078$190,518 09/30/2019
     IONS3,180,078$190,518 09/30/2019
Invesco Ltd.2,376,663$142,387 09/30/2019
     IONS2,376,663$142,387 09/30/2019
Price T Rowe Associates Inc. MD1,949,864$116,816 09/30/2019
     IONS1,949,864$116,816 09/30/2019
Renaissance Technologies LLC1,813,011$108,617 09/30/2019
     IONS1,813,011$108,617 09/30/2019
Two Sigma Advisers LP1,614,411$96,719 09/30/2019
     IONS1,614,411$96,719 09/30/2019
Geode Capital Management LLC1,428,037$85,494 09/30/2019
     IONS1,428,037$85,494 09/30/2019
American Century Companies Inc.1,371,814$82,185 09/30/2019
     IONS1,371,814$82,185 09/30/2019
Wells Fargo & Company MN1,040,580$62,342 09/30/2019
     IONS1,040,580$62,342 09/30/2019
First Trust Advisors LP988,916$59,246 09/30/2019
     IONS988,916$59,246 09/30/2019
BVF Inc. IL935,548$56,049 09/30/2019
     IONS935,548$56,049 09/30/2019
D. E. Shaw & Co. Inc. $52,025 09/30/2019
     IONS829,490$49,695 09/30/2019
     Call38,900$2,330 09/30/2019
Sumitomo Mitsui Trust Holdings Inc.865,463$51,850 09/30/2019
     IONS865,463$51,850 09/30/2019
Bank of America Corp DE830,460$49,753 09/30/2019
     IONS830,460$49,753 09/30/2019
Northern Trust Corp799,258$47,883 09/30/2019
     IONS799,258$47,883 09/30/2019
Pinnacle Associates Ltd.767,960$46,008 09/30/2019
     IONS767,960$46,008 09/30/2019
Raymond James & Associates732,804$43,902 09/30/2019
     IONS732,804$43,902 09/30/2019
Dowling & Yahnke LLC675,478$40,468 09/30/2019
     IONS675,478$40,468 09/30/2019
Two Sigma Investments LP661,005$39,601 09/30/2019
     IONS661,005$39,601 09/30/2019
APG Asset Management N.V.669,687$36,801 09/30/2019
     IONS669,687$36,801 09/30/2019
Charles Schwab Investment Management Inc.588,099$35,234 09/30/2019
     IONS588,099$35,234 09/30/2019
Janus Henderson Group PLC582,531$34,900 09/30/2019
     IONS582,531$34,900 09/30/2019
Goldman Sachs Group Inc.570,229$34,162 09/30/2019
     IONS570,229$34,162 09/30/2019
Bank of New York Mellon Corp $33,812 09/30/2019
     IONS547,235$32,786 09/30/2019
     NOTE900,000$1,026 09/30/2019
Nuveen Asset Management LLC499,187$29,907 09/30/2019
     IONS499,187$29,907 09/30/2019
Mitsubishi UFJ Trust & Banking Corp475,511$28,488 09/30/2019
     IONS475,511$28,488 09/30/2019
Swiss National Bank440,159$26,370 09/30/2019
     IONS440,159$26,370 09/30/2019
Sicart Associates LLC410,537$24,595 09/30/2019
     IONS410,537$24,595 09/30/2019
Tocqueville Asset Management L.P.409,307$24,522 09/30/2019
     IONS409,307$24,522 09/30/2019
Stifel Financial Corp406,739$24,362 09/30/2019
     IONS406,739$24,362 09/30/2019
Legal & General Group Plc390,248$23,372 09/30/2019
     IONS390,248$23,372 09/30/2019
Nikko Asset Management Americas Inc.364,091$21,813 09/30/2019
     IONS364,091$21,813 09/30/2019
Advent Capital Management DE $20,261 09/30/2019
     CONV17,756,000$20,261 09/30/2019
UBS Asset Management Americas Inc.337,234$20,204 09/30/2019
     IONS337,234$20,204 09/30/2019
First Light Asset Management LLC324,649$19,450 09/30/2019
     IONS324,649$19,450 09/30/2019
Sabby Management LLC $18,201 09/30/2019
     Call3,038$18,201 09/30/2019
California Public Employees Retirement System291,371$17,456 09/30/2019
     IONS291,371$17,456 09/30/2019
Altrinsic Global Advisors LLC289,198$17,326 09/30/2019
     IONS289,198$17,326 09/30/2019
Dimensional Fund Advisors LP280,785$16,820 09/30/2019
     IONS280,785$16,820 09/30/2019
New York State Common Retirement Fund271,673$16,276 09/30/2019
     IONS271,673$16,276 09/30/2019
Great Point Partners LLC270,000$16,176 09/30/2019
     IONS270,000$16,176 09/30/2019
AXA264,122$15,824 09/30/2019
     IONS264,122$15,824 09/30/2019
Franklin Resources Inc.263,600$15,792 09/30/2019
     IONS263,600$15,792 09/30/2019
Balyasny Asset Management LLC253,265$15,173 09/30/2019
     IONS253,265$15,173 09/30/2019
Royal Bank of Canada $14,910 09/30/2019
     IONS203,865$12,214 09/30/2019
     Call45,000$2,696 09/30/2019
Rothschild & Co. Asset Management US Inc.247,022$14,799 09/30/2019
     IONS247,022$14,799 09/30/2019
Lazard Asset Management LLC $14,287 09/30/2019
     Bond 30 360P2 U12,500,000$14,287 09/30/2019
UBS Group AG229,125$13,727 09/30/2019
     IONS229,125$13,727 09/30/2019
Morgan Stanley222,393$13,324 09/30/2019
     IONS222,393$13,324 09/30/2019
JPMorgan Chase & Co.215,291$12,899 09/30/2019
     IONS215,291$12,899 09/30/2019
California State Teachers Retirement System212,247$12,716 09/30/2019
     IONS212,247$12,716 09/30/2019
Millennium Management LLC $12,293 09/30/2019
     Call150,000$8,986 09/30/2019
     IONS55,205$3,307 09/30/2019
Gotham Asset Management LLC202,756$12,151 09/30/2019
     IONS202,756$12,151 09/30/2019
Deutsche Bank AG197,069$11,803 09/30/2019
     IONS197,069$11,803 09/30/2019
ARK Investment Management LLC196,669$11,782 09/30/2019
     IONS196,669$11,782 09/30/2019
Parametric Portfolio Associates LLC194,341$11,643 09/30/2019
     IONS194,341$11,643 09/30/2019
Peregrine Capital Management LLC194,329$11,642 09/30/2019
     IONS194,329$11,642 09/30/2019
BNP Paribas Arbitrage SA $11,366 09/30/2019
     BOND7,317,000$8,358 09/30/2019
     IONS50,201$3,008 09/30/2019
Tekla Capital Management LLC186,244$11,158 09/30/2019
     IONS186,244$11,158 09/30/2019
BLB&B Advisors LLC182,575$10,938 09/30/2019
     IONS182,575$10,938 09/30/2019
State Board of Administration of Florida Retirement System177,738$10,648 09/30/2019
     IONS177,738$10,648 09/30/2019
Pictet Asset Management Ltd.158,000$9,466 09/30/2019
     IONS158,000$9,466 09/30/2019
Jacobs Levy Equity Management Inc.156,840$9,396 09/30/2019
     IONS156,840$9,396 09/30/2019
DAVENPORT & Co LLC146,166$9,394 09/30/2019
     IONS146,166$9,394 09/30/2019
Squarepoint Ops LLC150,331$9,006 09/30/2019
     IONS150,331$9,006 09/30/2019
Canada Pension Plan Investment Board142,921$8,562 09/30/2019
     IONS142,921$8,562 09/30/2019
Rhumbline Advisers137,861$8,259 09/30/2019
     IONS137,861$8,259 09/30/2019
Sector Gamma AS131,514$7,879 09/30/2019
     IONS131,514$7,879 09/30/2019
Natixis Advisors L.P.123,386$7,392 09/30/2019
     IONS123,386$7,392 09/30/2019
Sonora Investment Management LLC117,009$7,010 09/30/2019
     IONS117,009$7,010 09/30/2019
Marshall Wace North America L.P.115,771$6,936 09/30/2019
     IONS115,771$6,936 09/30/2019
Citigroup Inc. $6,658 09/30/2019
     IONS161,331$9,666 09/30/2019
     Put78,100$4,679 09/30/2019
     Call27,900$1,671 09/30/2019
Credit Suisse AG106,875$6,403 09/30/2019
     IONS106,875$6,403 09/30/2019
Edmond DE Rothschild Holding S.A.106,120$6,358 09/30/2019
     IONS106,120$6,358 09/30/2019
Van ECK Associates Corp105,218$6,304 09/30/2019
     IONS105,218$6,304 09/30/2019
State of New Jersey Common Pension Fund D104,600$6,267 09/30/2019
     IONS104,600$6,267 09/30/2019
Rafferty Asset Management LLC98,163$5,881 09/30/2019
     IONS98,163$5,881 09/30/2019
Skandinaviska Enskilda Banken AB publ 94,600$5,667 09/30/2019
     IONS94,600$5,667 09/30/2019
State of Wisconsin Investment Board89,703$5,374 09/30/2019
     IONS89,703$5,374 09/30/2019
Sei Investments Co.72,142$4,322 09/30/2019
     IONS72,142$4,322 09/30/2019
Majedie Asset Management Ltd70,856$4,249 09/30/2019
     IONS70,856$4,249 09/30/2019
AMP Capital Investors Ltd70,974$4,191 09/30/2019
     IONS70,974$4,191 09/30/2019
Alliancebernstein L.P.68,584$4,109 09/30/2019
     IONS68,584$4,109 09/30/2019
Guggenheim Capital LLC67,342$4,034 09/30/2019
     IONS67,342$4,034 09/30/2019
Asset Management One Co. Ltd.65,368$3,917 09/30/2019
     IONS65,368$3,917 09/30/2019
Decatur Capital Management Inc.64,176$3,845 09/30/2019
     IONS64,176$3,845 09/30/2019
Voya Investment Management LLC63,730$3,818 09/30/2019
     IONS63,730$3,818 09/30/2019
Citadel Advisors LLC $3,773 09/30/2019
     Call83,400$4,996 09/30/2019
     Put69,700$4,176 09/30/2019
     IONS49,280$2,953 09/30/2019
Capital Impact Advisors LLC62,434$3,688 09/30/2019
     IONS62,434$3,688 09/30/2019
Susquehanna International Group LLP $3,643 09/30/2019
     Put677,800$40,607 09/30/2019
     Call514,200$30,806 09/30/2019
     IONS224,395$13,444 09/30/2019
Teachers Retirement System of The State of Kentucky59,526$3,566 09/30/2019
     IONS59,526$3,566 09/30/2019
Envestnet Asset Management Inc.57,390$3,438 09/30/2019
     IONS57,390$3,438 09/30/2019
HRT Financial LLC54,813$3,283 09/30/2019
     IONS54,813$3,283 09/30/2019
Public Employees Retirement System of Ohio54,423$3,260 09/30/2019
     IONS54,423$3,260 09/30/2019
Man Group plc54,248$3,250 09/30/2019
     IONS54,248$3,250 09/30/2019
AustralianSuper Pty Ltd53,148$3,184 09/30/2019
     IONS53,148$3,184 09/30/2019
Polar Capital LLP50,000$2,996 09/30/2019
     IONS50,000$2,996 09/30/2019
Capital Fund Management S.A. $2,839 09/30/2019
     IONS43,206$2,588 09/30/2019
     Call8,700$521 09/30/2019
     Put4,500$270 09/30/2019
TD Asset Management Inc.47,103$2,822 09/30/2019
     IONS47,103$2,822 09/30/2019
International Biotechnology Trust PLC46,181$2,767 09/30/2019
     IONS46,181$2,767 09/30/2019
LPL Financial LLC46,095$2,762 09/30/2019
     IONS46,095$2,762 09/30/2019
Kiwi Wealth Investments Limited Partnership45,197$2,708 09/30/2019
     IONS45,197$2,708 09/30/2019
Janney Montgomery Scott LLC44,769$2,682 09/30/2019
     IONS44,769$2,682 09/30/2019
Gateway Investment Advisers LLC42,246$2,531 09/30/2019
     IONS42,246$2,531 09/30/2019
ProShare Advisors LLC41,040$2,459 09/30/2019
     IONS41,040$2,459 09/30/2019
Capital Counsel LLC NY39,380$2,359 09/30/2019
     IONS39,380$2,359 09/30/2019
Treasurer of the State of North Carolina39,180$2,347 09/30/2019
     IONS39,180$2,347 09/30/2019
First Quadrant L P CA37,414$2,241 09/30/2019
     IONS37,414$2,241 09/30/2019
Andra AP fonden36,700$2,199 09/30/2019
     IONS36,700$2,199 09/30/2019
Bridgeway Capital Management Inc.36,200$2,169 09/30/2019
     IONS36,200$2,169 09/30/2019
Principal Financial Group Inc.35,923$2,152 09/30/2019
     IONS35,923$2,152 09/30/2019
Amundi Pioneer Asset Management Inc.35,689$2,138 09/30/2019
     IONS35,689$2,138 09/30/2019
Amalgamated Bank32,487$1,946 09/30/2019
     IONS32,487$1,946 09/30/2019
Employees Retirement System of Texas32,409$1,942 09/30/2019
     IONS32,409$1,942 09/30/2019
Fjarde AP Fonden Fourth Swedish National Pension Fund31,900$1,911 09/30/2019
     IONS31,900$1,911 09/30/2019
Circle Wealth Management LLC31,150$1,866 09/30/2019
     IONS31,150$1,866 09/30/2019
AJO LP30,748$1,842 09/30/2019
     IONS30,748$1,842 09/30/2019
Tanaka Capital Management Inc.30,677$1,838 09/30/2019
     IONS30,677$1,838 09/30/2019
Jefferies Group LLC30,492$1,827 09/30/2019
     IONS30,492$1,827 09/30/2019
Profund Advisors LLC29,425$1,763 09/30/2019
     IONS29,425$1,763 09/30/2019
WINTON GROUP Ltd27,524$1,649 09/30/2019
     IONS27,524$1,649 09/30/2019
Castleark Management LLC27,125$1,625 09/30/2019
     IONS27,125$1,625 09/30/2019
Oaktree Capital Management LP $1,583 09/30/2019
     CV SR UNSEC NT1,386,000$1,583 09/30/2019
Russell Investments Group Ltd. $1,579 09/30/2019
     IONS22,590$1,352 09/30/2019
     Corporate200,000$227 09/30/2019
Bank of Montreal Can25,688$1,539 09/30/2019
     IONS25,688$1,539 09/30/2019
BOKF NA25,363$1,519 09/30/2019
     IONS25,363$1,519 09/30/2019
AQR Capital Management LLC24,793$1,485 09/30/2019
     IONS24,793$1,485 09/30/2019
PFS Investments Inc.24,372$1,460 09/30/2019
     IONS24,372$1,460 09/30/2019
Utah Retirement Systems24,309$1,457 09/30/2019
     IONS24,309$1,457 09/30/2019
Hsbc Holdings PLC23,727$1,422 09/30/2019
     IONS23,727$1,422 09/30/2019
Vestmark Advisory Solutions Inc.23,373$1,400 09/30/2019
     IONS23,373$1,400 09/30/2019
Creative Planning23,285$1,395 09/30/2019
     IONS23,285$1,395 09/30/2019
Aperio Group LLC22,535$1,350 09/30/2019
     IONS22,535$1,350 09/30/2019
Xact Kapitalforvaltning AB22,311$1,337 09/30/2019
     IONS22,311$1,337 09/30/2019
Zurcher Kantonalbank Zurich Cantonalbank 21,974$1,316 09/30/2019
     IONS21,974$1,316 09/30/2019
Stephens Inc. AR21,869$1,310 09/30/2019
     IONS21,869$1,310 09/30/2019
Toronto Dominion Bank21,420$1,283 09/30/2019
     IONS21,420$1,283 09/30/2019
Macquarie Group Ltd.20,623$1,236 09/30/2019
     IONS20,623$1,236 09/30/2019
Reynders McVeigh Capital Management LLC20,590$1,234 09/30/2019
     IONS20,590$1,234 09/30/2019
Opus Point Partners Management LLC20,124$1,206 09/30/2019
     IONS20,124$1,206 09/30/2019
Nomura Asset Management Co. Ltd.20,000$1,198 09/30/2019
     IONS20,000$1,198 09/30/2019
Eaton Vance Management19,653$1,177 09/30/2019
     IONS19,653$1,177 09/30/2019
Commonwealth Equity Services LLC19,602$1,174 09/30/2019
     IONS19,602$1,174 09/30/2019
Public Employees Retirement Association of Colorado19,566$1,172 09/30/2019
     IONS19,566$1,172 09/30/2019
Mitsubishi UFJ Kokusai Asset Management Co. Ltd.19,383$1,161 09/30/2019
     IONS19,383$1,161 09/30/2019
Advisors Asset Management Inc.19,001$1,138 09/30/2019
     IONS19,001$1,138 09/30/2019
Connor Clark & Lunn Investment Management Ltd.18,825$1,128 09/30/2019
     IONS18,825$1,128 09/30/2019
Arden Trust Co18,688$1,120 09/30/2019
     IONS18,688$1,120 09/30/2019
Alexandria Capital LLC18,643$1,117 09/30/2019
     IONS18,643$1,117 09/30/2019
Schroder Investment Management Group18,647$1,101 09/30/2019
     IONS18,647$1,101 09/30/2019
BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp18,240$1,093 09/30/2019
     IONS18,240$1,093 09/30/2019
Lincoln National Corp17,974$1,077 09/30/2019
     IONS17,974$1,077 09/30/2019
First Republic Investment Management Inc.17,843$1,069 09/30/2019
     IONS17,843$1,069 09/30/2019
Advisor Group Inc.17,565$1,052 09/30/2019
     IONS17,565$1,052 09/30/2019
Ladenburg Thalmann Financial Services Inc.17,112$1,025 09/30/2019
     IONS17,112$1,025 09/30/2019
Raymond James Financial Services Advisors Inc.16,992$1,018 09/30/2019
     IONS16,992$1,018 09/30/2019
Shell Asset Management Co.16,846$1,009 09/30/2019
     IONS16,846$1,009 09/30/2019
Starfire Investment Advisers Inc.16,543$991 09/30/2019
     IONS16,543$991 09/30/2019
Victory Capital Management Inc.16,424$984 09/30/2019
     IONS16,424$984 09/30/2019
Oxford Asset Management LLP16,113$965 09/30/2019
     IONS16,113$965 09/30/2019
Arrowstreet Capital Limited Partnership16,000$959 09/30/2019
     IONS16,000$959 09/30/2019
Grandfield & Dodd LLC15,821$948 09/30/2019
     IONS15,821$948 09/30/2019
Wrapmanager Inc.15,798$946 09/30/2019
     IONS15,798$946 09/30/2019
Teacher Retirement System of Texas15,729$942 09/30/2019
     IONS15,729$942 09/30/2019
Allen Investment Management LLC15,680$939 09/30/2019
     IONS15,680$939 09/30/2019
Prudential Financial Inc.15,601$935 09/30/2019
     IONS15,601$935 09/30/2019
Wexford Capital LP15,385$922 09/30/2019
     IONS15,385$922 09/30/2019
North Star Asset Management Inc.15,200$911 09/30/2019
     IONS15,200$911 09/30/2019
Blair William & Co. IL14,578$873 09/30/2019
     IONS14,578$873 09/30/2019
DNB Asset Management AS14,289$856 09/30/2019
     IONS14,289$856 09/30/2019
Comerica Bank15,674$844 09/30/2019
     IONS15,674$844 09/30/2019
M&T Bank Corp14,054$843 09/30/2019
     IONS14,054$843 09/30/2019
Castle Rock Wealth Management LLC14,863$842 09/30/2019
     IONS14,863$842 09/30/2019
Walleye Capital LLC $809 09/30/2019
     Call14,400$863 09/30/2019
     Put900$54 09/30/2019
RMB Capital Management LLC13,178$789 09/30/2019
     IONS13,178$789 09/30/2019
Oppenheimer Asset Management Inc.12,968$777 09/30/2019
     IONS12,968$777 09/30/2019
Ellington Management Group LLC12,800$767 09/30/2019
     IONS12,800$767 09/30/2019
Robeco Institutional Asset Management B.V.12,459$747 09/30/2019
     IONS12,459$747 09/30/2019
IFM Investors Pty Ltd12,234$733 09/30/2019
     IONS12,234$733 09/30/2019
Horizon Kinetics Asset Management LLC12,200$731 09/30/2019
     IONS12,200$731 09/30/2019
Allstate Corp12,110$726 09/30/2019
     IONS12,110$726 09/30/2019
NJ State Employees Deferred Compensation Plan12,000$719 09/30/2019
     IONS12,000$719 09/30/2019
HighTower Advisors LLC12,006$715 09/30/2019
     IONS12,006$715 09/30/2019
Chicago Equity Partners LLC11,270$675 09/30/2019
     IONS11,270$675 09/30/2019
Virtus ETF Advisers LLC11,156$668 09/30/2019
     IONS11,156$668 09/30/2019
Nissay Asset Management Corp Japan ADV11,038$661 09/30/2019
     IONS11,038$661 09/30/2019
Coastal Investment Advisors Inc.10,988$654 09/30/2019
     IONS10,988$654 09/30/2019
AlphaCrest Capital Management LLC10,700$641 09/30/2019
     IONS10,700$641 09/30/2019
Nicollet Investment Management Inc.10,630$637 09/30/2019
     IONS10,630$637 09/30/2019
Westpac Banking Corp10,594$635 09/30/2019
     IONS10,594$635 09/30/2019
SG Americas Securities LLC10,206$611 09/30/2019
     IONS10,206$611 09/30/2019
Centiva Capital LP $607 09/30/2019
     Call43,100$2,582 09/30/2019
     Put40,300$2,414 09/30/2019
     IONS7,336$439 09/30/2019
Weiss Multi Strategy Advisers LLC10,000$599 09/30/2019
     IONS10,000$599 09/30/2019
Piedmont Investment Advisors Inc.9,598$575 09/30/2019
     IONS9,598$575 09/30/2019
KBC Group NV9,586$574 09/30/2019
     IONS9,586$574 09/30/2019
BB&T Securities LLC9,561$572 09/30/2019
     IONS9,561$572 09/30/2019
Metropolitan Life Insurance Co NY9,428$565 09/30/2019
     IONS9,428$565 09/30/2019
PNC Financial Services Group Inc.8,393$502 09/30/2019
     IONS8,393$502 09/30/2019
Hanseatic Management Services Inc.8,314$498 09/30/2019
     IONS8,314$498 09/30/2019
Ameriprise Financial Inc.8,197$490 09/30/2019
     IONS8,197$490 09/30/2019
Northeast Financial Consultants Inc8,000$479 09/30/2019
     IONS8,000$479 09/30/2019
Prospera Financial Services Inc7,960$477 09/30/2019
     IONS7,960$477 09/30/2019
Barclays PLC $470 09/30/2019
     Put103,600$6,207 09/30/2019
     Call57,300$3,433 09/30/2019
     IONS54,159$3,244 09/30/2019
Ostrum Asset Management $457 09/30/2019
     Convertible Bond400$457 09/30/2019
Standard Life Aberdeen plc7,506$450 09/30/2019
     IONS7,506$450 09/30/2019
Knights of Columbus Asset Advisors LLC7,381$442 09/30/2019
     IONS7,381$442 09/30/2019
Fifth Third Bancorp7,282$436 09/30/2019
     IONS7,282$436 09/30/2019
Sumitomo Mitsui DS Asset Management Company Ltd7,182$430 09/30/2019
     IONS7,182$430 09/30/2019
Keybank National Association OH7,117$426 09/30/2019
     IONS7,117$426 09/30/2019
Rathbone Brothers plc6,945$416 09/30/2019
     IONS6,945$416 09/30/2019
Achmea Investment Management B.V.6,928$415 09/30/2019
     IONS6,928$415 09/30/2019
XR Securities LLC $396 09/30/2019
     IONS7,327$439 09/30/2019
     Put16,000$43 09/30/2019
Allianz Asset Management GmbH6,407$384 09/30/2019
     IONS6,407$384 09/30/2019
CSS LLC IL $383 09/30/2019
     Put17,200$1,031 09/30/2019
     Call15,000$899 09/30/2019
     IONS8,589$515 09/30/2019
Two Sigma Securities LLC $377 09/30/2019
     Call6,300$377 09/30/2019
FDx Advisors Inc.6,136$368 09/30/2019
     IONS6,136$368 09/30/2019
AE Wealth Management LLC6,119$367 09/30/2019
     IONS6,119$367 09/30/2019
National Asset Management Inc.6,080$365 09/30/2019
     IONS6,080$365 09/30/2019
Beirne Wealth Consulting Services LLC5,960$357 09/30/2019
     IONS5,960$357 09/30/2019
Bailard Inc.5,900$353 09/30/2019
     IONS5,900$353 09/30/2019
Daiwa Securities Group Inc.5,860$351 09/30/2019
     IONS5,860$351 09/30/2019
Baird Financial Group Inc.5,841$350 09/30/2019
     IONS5,841$350 09/30/2019
Cubist Systematic Strategies LLC5,812$348 09/30/2019
     IONS5,812$348 09/30/2019
Nisa Investment Advisors LLC5,415$324 09/30/2019
     IONS5,415$324 09/30/2019
Raymond James Trust N.A.5,337$320 09/30/2019
     IONS5,337$320 09/30/2019
Cigna Investments Inc. New5,700$318 09/30/2019
     IONS5,700$318 09/30/2019
Alpine Woods Capital Investors LLC5,300$318 09/30/2019
     IONS5,300$318 09/30/2019
Buckingham Asset Management LLC5,212$312 09/30/2019
     IONS5,212$312 09/30/2019
Nordea Investment Management AB5,156$309 09/30/2019
     IONS5,156$309 09/30/2019
Whitener Capital Management Inc.5,000$299 09/30/2019
     IONS5,000$299 09/30/2019
ETRADE Capital Management LLC4,961$297 09/30/2019
     IONS4,961$297 09/30/2019
Suntrust Banks Inc.4,868$292 09/30/2019
     IONS4,868$292 09/30/2019
Brown Advisory Securities LLC4,800$288 09/30/2019
     IONS4,800$288 09/30/2019
Nomura Holdings Inc. $286 09/30/2019
     CNV500,000$286 09/30/2019
Walleye Trading LLC $276 09/30/2019
     Call5,400$324 09/30/2019
     Put800$48 09/30/2019
Mirae Asset Global Investments Co. Ltd.4,605$276 09/30/2019
     IONS4,605$276 09/30/2019
Regions Financial Corp4,567$274 09/30/2019
     IONS4,567$274 09/30/2019
CIBC Asset Management Inc4,503$270 09/30/2019
     IONS4,503$270 09/30/2019
Seeyond4,463$267 09/30/2019
     IONS4,463$267 09/30/2019
Mercer Global Advisors Inc. ADV4,342$260 09/30/2019
     IONS4,342$260 09/30/2019
World Asset Management Inc4,269$256 09/30/2019
     IONS4,269$256 09/30/2019
First Allied Advisory Services Inc.4,294$252 09/30/2019
     IONS4,294$252 09/30/2019
Gideon Capital Advisors Inc.4,111$246 09/30/2019
     IONS4,111$246 09/30/2019
RFG Advisory LLC4,082$245 09/30/2019
     IONS4,082$245 09/30/2019
Woodley Farra Manion Portfolio Management Inc.4,067$244 09/30/2019
     IONS4,067$244 09/30/2019
LMR Partners LLP4,028$241 09/30/2019
     IONS4,028$241 09/30/2019
QS Investors LLC4,000$240 09/30/2019
     IONS4,000$240 09/30/2019
Checchi Capital Advisers LLC3,978$238 09/30/2019
     IONS3,978$238 09/30/2019
Icon Wealth Partners LLC3,938$236 09/30/2019
     IONS3,938$236 09/30/2019
Cannell Peter B & Co. Inc.3,850$231 09/30/2019
     IONS3,850$231 09/30/2019
Berkshire Asset Management LLC PA3,861$231 09/30/2019
     IONS3,861$231 09/30/2019
First City Capital Management Inc.3,830$229 09/30/2019
     IONS3,830$229 09/30/2019
Jane Street Group LLC3,750$225 09/30/2019
     IONS3,750$225 09/30/2019
Steward Partners Investment Advisory LLC3,747$224 09/30/2019
     IONS3,747$224 09/30/2019
Atria Investments LLC3,688$221 09/30/2019
     IONS3,688$221 09/30/2019
Rockefeller Capital Management L.P.3,678$220 09/30/2019
     IONS3,678$220 09/30/2019
Fiduciary Trust Co.3,657$219 09/30/2019
     IONS3,657$219 09/30/2019
The Manufacturers Life Insurance Company 3,651$216 09/30/2019
     IONS3,651$216 09/30/2019
BNP PARIBAS ASSET MANAGEMENT Holding S.A.3,593$215 09/30/2019
     IONS3,593$215 09/30/2019
Granahan Investment Management Inc. MA3,576$214 09/30/2019
     IONS3,576$214 09/30/2019
Cambridge Investment Research Advisors Inc.3,468$208 09/30/2019
     IONS3,468$208 09/30/2019
Prestige Wealth Management Group LLC3,473$208 09/30/2019
     IONS3,473$208 09/30/2019
Highland Capital Management LLC3,440$206 09/30/2019
     IONS3,440$206 09/30/2019
MML Investors Services LLC3,430$205 09/30/2019
     IONS3,430$205 09/30/2019
IFP Advisors Inc3,232$192 09/30/2019
     IONS3,232$192 09/30/2019
American International Group Inc.3,129$187 09/30/2019
     IONS3,129$187 09/30/2019
US Bancorp DE2,413$145 09/30/2019
     IONS2,413$145 09/30/2019
ETF Managers Group LLC2,344$138 09/30/2019
     IONS2,344$138 09/30/2019
Panagora Asset Management Inc.2,200$132 09/30/2019
     IONS2,200$132 09/30/2019
Benjamin F. Edwards & Company Inc.2,089$125 09/30/2019
     IONS2,089$125 09/30/2019
Kistler Tiffany Companies LLC2,006$120 09/30/2019
     IONS2,006$120 09/30/2019
CSat Investment Advisory L.P.1,824$109 09/30/2019
     IONS1,824$109 09/30/2019
Federated Investors Inc. PA1,719$103 09/30/2019
     IONS1,719$103 09/30/2019
Northwestern Mutual Wealth Management Co.1,564$93 09/30/2019
     IONS1,564$93 09/30/2019
Livforsakringsbolaget Skandia Omsesidigt1,500$90 09/30/2019
     IONS1,500$90 09/30/2019
NEXT Financial Group Inc1,381$83 09/30/2019
     IONS1,381$83 09/30/2019
First Manhattan Co.1,275$76 09/30/2019
     IONS1,275$76 09/30/2019
Institutional & Family Asset Management LLC1,036$62 09/30/2019
     IONS1,036$62 09/30/2019
Perkins Coie Trust Co1,000$60 09/30/2019
     IONS1,000$60 09/30/2019
Riggs Asset Managment Co. Inc.1,000$59 09/30/2019
     IONS1,000$59 09/30/2019
Advisory Services Network LLC907$58 09/30/2019
     IONS907$58 09/30/2019
Bessemer Group Inc.950$57 09/30/2019
     IONS950$57 09/30/2019
LS Investment Advisors LLC932$56 09/30/2019
     IONS932$56 09/30/2019
Bradley Foster & Sargent Inc. CT804$49 09/30/2019
     IONS804$49 09/30/2019
Parallel Advisors LLC820$49 09/30/2019
     IONS820$49 09/30/2019
Laurel Wealth Advisors LLC800$48 09/30/2019
     IONS800$48 09/30/2019
Hall Laurie J Trustee790$47 09/30/2019
     IONS790$47 09/30/2019
Quantbot Technologies LP797$47 09/30/2019
     IONS797$47 09/30/2019
FinTrust Capital Advisors LLC732$44 09/30/2019
     IONS732$44 09/30/2019
Evoke Wealth LLC685$41 09/30/2019
     IONS685$41 09/30/2019
Signaturefd LLC673$40 09/30/2019
     IONS673$40 09/30/2019
Venturi Wealth Management LLC669$40 09/30/2019
     IONS669$40 09/30/2019
Rehmann Capital Advisory Group592$38 06/30/2019
     IONS592$38 06/30/2019
Carroll Financial Associates Inc.628$37 09/30/2019
     IONS628$37 09/30/2019
Quest Capital Management Inc. ADV597$36 09/30/2019
     IONS597$36 09/30/2019
Balentine LLC606$36 09/30/2019
     IONS606$36 09/30/2019
Marshall Wace LLP561$34 09/30/2019
     IONS561$34 09/30/2019
Brown Brothers Harriman & Co.550$33 09/30/2019
     IONS550$33 09/30/2019
Twin Tree Management LP538$32 09/30/2019
     IONS538$32 09/30/2019
Credit Agricole S A500$30 09/30/2019
     IONS500$30 09/30/2019
Captrust Financial Advisors496$30 09/30/2019
     IONS496$30 09/30/2019
Ellis Investment Partners LLC500$28 09/30/2019
     IONS500$28 09/30/2019
Sowell Financial Services LLC452$27 09/30/2019
     IONS452$27 09/30/2019
Salem Investment Counselors Inc.419$25 09/30/2019
     IONS419$25 09/30/2019
First Interstate Bank419$25 09/30/2019
     IONS419$25 09/30/2019
CWM LLC406$24 09/30/2019
     IONS406$24 09/30/2019
Reilly Financial Advisors LLC320$19 09/30/2019
     IONS320$19 09/30/2019
Citizens Financial Group Inc RI298$18 09/30/2019
     IONS298$18 09/30/2019
Cornerstone Advisors Inc.307$18 09/30/2019
     IONS307$18 09/30/2019
Candriam Luxembourg S.C.A.293,200$18 09/30/2019
     IONS293,200$18 09/30/2019
Ameritas Investment Corp262$16 09/30/2019
     IONS262$16 09/30/2019
Liberty Wealth Management LLC266$16 09/30/2019
     IONS266$16 09/30/2019
Cullen Frost Bankers Inc.257$15 09/30/2019
     IONS257$15 09/30/2019
Huntington National Bank246$15 09/30/2019
     IONS246$15 09/30/2019
AllSquare Wealth Management LLC198$12 09/30/2019
     IONS198$12 09/30/2019
Glassman Wealth Services205$12 09/30/2019
     IONS205$12 09/30/2019
Quadrant Capital Group LLC218$12 09/30/2019
     IONS218$12 09/30/2019
Trustcore Financial Services LLC195$12 09/30/2019
     IONS195$12 09/30/2019
Fred Alger Management LLC190$11 09/30/2019
     IONS190$11 09/30/2019
Glenmede Trust Co. NA206$11 09/30/2019
     IONS206$11 09/30/2019
Harel Insurance Investments & Financial Services Ltd.165$10 09/30/2019
     IONS165$10 09/30/2019
Winslow Evans & Crocker Inc.150$10 09/30/2019
     IONS150$10 09/30/2019
Shine Investment Advisory Services Inc.150$9 09/30/2019
     IONS150$9 09/30/2019
Advantage Investment Management LLC150$9 09/30/2019
     IONS150$9 09/30/2019
Garrett Wealth Advisory Group LLC142$9 09/30/2019
     IONS142$9 09/30/2019
Prime Capital Investment Advisors LLC158$9 09/30/2019
     IONS158$9 09/30/2019
CLS Investments LLC138$8 09/30/2019
     IONS138$8 09/30/2019
AGF Investments LLC128$8 09/30/2019
     IONS128$8 09/30/2019
Golden State Wealth Management LLC126$8 09/30/2019
     IONS126$8 09/30/2019
Weil Company Inc.120$7 09/30/2019
     IONS120$7 09/30/2019
Gradient Investments LLC115$7 09/30/2019
     IONS115$7 09/30/2019
Enterprise Financial Services Corp100$6 09/30/2019
     IONS100$6 09/30/2019
Whittier Trust Co.100$6 09/30/2019
     IONS100$6 09/30/2019
Prelude Capital Management LLC108$6 09/30/2019
     IONS108$6 09/30/2019
Manchester Capital Management LLC101$6 09/30/2019
     IONS101$6 09/30/2019
AdvisorNet Financial Inc99$6 09/30/2019
     IONS99$6 09/30/2019
Cutler Group LP $6 09/30/2019
     Call1,000$6 09/30/2019
Tower Research Capital LLC TRC 83$5 09/30/2019
     IONS83$5 09/30/2019
Blume Capital Management Inc.90$5 09/30/2019
     IONS90$5 09/30/2019
Berman Capital Advisors LLC98$5 09/30/2019
     IONS98$5 09/30/2019
Global Wealth Management Investment Advisory Inc.80$5 09/30/2019
     IONS80$5 09/30/2019
CENTRAL TRUST Co60$4 09/30/2019
     IONS60$4 09/30/2019
TCI Wealth Advisors Inc.60$4 09/30/2019
     IONS60$4 09/30/2019
Meeder Asset Management Inc.54$3 09/30/2019
     IONS54$3 09/30/2019
Earnest Partners LLC49$3 09/30/2019
     IONS49$3 09/30/2019
Wealthcare Advisory Partners LLC55$3 09/30/2019
     IONS55$3 09/30/2019
Assetmark Inc.25$2 09/30/2019
     IONS25$2 09/30/2019
SRS Capital Advisors Inc.30$2 09/30/2019
     IONS30$2 09/30/2019
FTB Advisors Inc.35$2 09/30/2019
     IONS35$2 09/30/2019
Tortoise Investment Management LLC26$2 09/30/2019
     IONS26$2 09/30/2019
Bedel Financial Consulting Inc.38$2 09/30/2019
     IONS38$2 09/30/2019
Private Capital Group LLC31$2 09/30/2019
     IONS31$2 09/30/2019
Versant Capital Management Inc46$2 09/30/2019
     IONS46$2 09/30/2019
Global Retirement Partners LLC41$2 09/30/2019
     IONS41$2 09/30/2019
Semmax Financial Advisors Inc.39$2 09/30/2019
     IONS39$2 09/30/2019
Trust Co. of Vermont16$1 09/30/2019
     IONS16$1 09/30/2019
San Francisco Sentry Investment Group CA17$1 09/30/2019
     IONS17$1 09/30/2019
Cranbrook Wealth Management LLC25$1 09/30/2019
     IONS25$1 09/30/2019
Valeo Financial Advisors LLC15$1 09/30/2019
     IONS15$1 09/30/2019
Proequities Inc. $0 09/30/2019
     Put0$0 09/30/2019
     Call0$0 09/30/2019
     IONS0$0 09/30/2019
Allworth Financial LP7$0 09/30/2019
     IONS7$0 09/30/2019
Gemmer Asset Management LLC3$0 09/30/2019
     IONS3$0 09/30/2019
Stratos Wealth Partners LTD.8$0 09/30/2019
     IONS8$0 09/30/2019
Aspire Private Capital LLC8$0 09/30/2019
     IONS8$0 09/30/2019
Wolverine Trading LLC $-2,933 09/30/2019
     Put210,600$12,438 09/30/2019
     IONS96,140$5,678 09/30/2019
     Call64,800$3,827 09/30/2019
Simplex Trading LLC $-4,479 09/30/2019
     Put1,243$7,446 09/30/2019
     Call333$1,995 09/30/2019
     IONS16,235$972 09/30/2019
PEAK6 Investments LLC18,900$-8,757 09/30/2019
     Put219,200$13,132 09/30/2019
     IONS54,127$3,243 09/30/2019
     Call18,900$1,132 09/30/2019

See Summary: Institutional Holders of IONS
See Details: Top 10 Hedge Funds Holding IONS
Also See: IONS Holdings Changes

Quotes delayed 20 minutes

Funds Holding IONS | www.HoldingsChannel.com

Copyright © 2013 - 2019, All Rights Reserved Nothing in Holdings Channel is intended to be investment advice, nor does it represent the opinion of, counsel from, or recommendations by BNK Invest Inc. or any of its affiliates, subsidiaries or partners. None of the information contained herein constitutes a recommendation that any particular security, portfolio, transaction, or investment strategy is suitable for any specific person. All viewers agree that under no circumstances will BNK Invest, Inc,. its subsidiaries, partners, officers, employees, affiliates, or agents be held liable for any loss or damage caused by your reliance on information obtained. By visiting, using or viewing this site, you agree to the following Full Disclaimer & Terms of Use and Privacy Policy. Video widget and videos powered by Market News Video. Quote data delayed at least 20 minutes; data powered by Ticker Technologies, and Mergent. Contact Holdings Channel; Meet Our Editorial Staff.