On this page, we present all of the funds holding IONS from our database of 13F filers, detailed in the table below. The first column indicates the name of each of the funds holding IONS, with a link to that fund's top holdings. The next columns indicate the amount of IONS stock held by each of the funds holding IONS, followed by the IONS position size held by the fund, and lastly the date of the quarterly filing period the data represents. In total, we count 380 funds holding IONS within the last two filing periods in our coverage universe of 13F filers, with the largest position size having been reported by Steelhead Partners LLC. For more details on the positions held by Steelhead Partners LLC (or by any of the other funds holding IONS), click the fund name in the "Holder" column of the funds-holding-IONS table below.

Holder	Amount	Position Size ($ in 1000's)	As of
Steelhead Partners LLC		$58,672,629	12/31/2023
NOTE 4 0	55,490,000	$58,672,629	12/31/2023
FMR LLC	21,520,872	$1,088,741	12/31/2023
IONS	21,520,872	$1,088,741	12/31/2023
Vanguard Group Inc.	14,203,481	$718,554	12/31/2023
IONS	14,203,481	$718,554	12/31/2023
T. Rowe Price Investment Management Inc.	13,201,453	$667,862	12/31/2023
IONS	13,201,453	$667,862	12/31/2023
BlackRock Inc.		$482,692	12/31/2023
IONS	9,057,530	$458,220	12/31/2023
NOTE 4 0	23,262,000	$24,472	12/31/2023
Bellevue Group AG	8,713,987	$440,841	12/31/2023
IONS	8,713,987	$440,841	12/31/2023
Clearbridge Investments LLC	4,707,480	$238,151	12/31/2023
IONS	4,707,480	$238,151	12/31/2023
Wellington Management Group LLP	4,616,978	$233,573	12/31/2023
IONS	4,616,978	$233,573	12/31/2023
State Street Corp		$217,658	12/31/2023
IONS	4,008,797	$202,805	12/31/2023
NOTE 4 0	14,075,000	$14,853	12/31/2023
Price T Rowe Associates Inc. MD	4,255,074	$215,265	12/31/2023
IONS	4,255,074	$215,265	12/31/2023
Pictet Asset Management Holding SA	3,518,317	$177,992	12/31/2023
IONS	3,518,317	$177,992	12/31/2023
Tweedy Browne Co LLC	3,454,676	$174,772	12/31/2023
IONS	3,454,676	$174,772	12/31/2023
Macquarie Group Ltd.		$160,008	12/31/2023
IONS	3,088,235	$156,234	12/31/2023
NOTE 0	3,903,000	$3,774	12/31/2023
BVF Inc. IL	2,428,613	$122,864	12/31/2023
IONS	2,428,613	$122,864	12/31/2023
Geode Capital Management LLC	2,275,931	$115,158	12/31/2023
IONS	2,275,931	$115,158	12/31/2023
Orbimed Advisors LLC	2,064,797	$104,458	12/31/2023
IONS	2,064,797	$104,458	12/31/2023
Farallon Capital Management LLC	1,555,020	$78,668	12/31/2023
IONS	1,555,020	$78,668	12/31/2023
Adage Capital Partners GP L.L.C.	1,385,300	$70,082	12/31/2023
IONS	1,385,300	$70,082	12/31/2023
Morgan Stanley		$68,196	12/31/2023
IONS	1,090,263	$55,156	12/31/2023
NOTE 4 0	6,350,000	$6,675	12/31/2023
NOTE 0	6,735,000	$6,365	12/31/2023
Citadel Advisors LLC		$67,840	12/31/2023
NOTE 4 0	50,880,000	$53,720	12/31/2023
IONS	252,528	$12,775	12/31/2023
Call	46,400	$2,347	12/31/2023
Put	19,800	$1,002	12/31/2023
Charles Schwab Investment Management Inc.	1,275,319	$64,518	12/31/2023
IONS	1,275,319	$64,518	12/31/2023
Deep Track Capital LP	1,249,068	$63,190	12/31/2023
IONS	1,249,068	$63,190	12/31/2023
ARK Investment Management LLC	1,399,852	$60,684	03/31/2024
IONS	1,399,852	$60,684	03/31/2024
Norges Bank	1,171,936	$59,288	12/31/2023
IONS	1,171,936	$59,288	12/31/2023
First Trust Advisors LP	1,097,730	$55,534	12/31/2023
IONS	1,097,730	$55,534	12/31/2023
Wells Fargo & Company MN		$52,656	12/31/2023
IONS	594,250	$30,063	12/31/2023
NOTE 4 0	20,237,000	$21,348	12/31/2023
NOTE 0	1,314,000	$1,245	12/31/2023
Point72 Asset Management L.P.	968,800	$49,012	12/31/2023
IONS	968,800	$49,012	12/31/2023
Lazard Asset Management LLC		$48,674	12/31/2023
Bond 30 360P2 U	45,733,000	$48,339	12/31/2023
IONS	6,641	$335	12/31/2023
TD Asset Management Inc.	956,852	$48,407	12/31/2023
IONS	956,852	$48,407	12/31/2023
JPMorgan Chase & Co.		$47,607	12/31/2023
IONS	941,032	$47,607	12/31/2023
Put	30,000	$1,518	12/31/2023
Call	30,000	$1,518	12/31/2023
Millennium Management LLC	890,325	$45,042	12/31/2023
IONS	890,325	$45,042	12/31/2023
Camber Capital Management LP	865,000	$43,760	12/31/2023
IONS	865,000	$43,760	12/31/2023
Royal Bank of Canada		$42,947	12/31/2023
IONS	774,246	$39,169	12/31/2023
NOTE	3,568,000	$3,753	12/31/2023
Call	500	$25	12/31/2023
Capital World Investors	839,463	$42,468	12/31/2023
IONS	839,463	$42,468	12/31/2023
Two Sigma Investments LP	801,448	$40,545	12/31/2023
IONS	801,448	$40,545	12/31/2023
Two Sigma Advisers LP	777,011	$39,309	12/31/2023
IONS	777,011	$39,309	12/31/2023
Sonora Investment Management Group LLC		$37,076	12/31/2023
NOTE 0	16,978,000	$16,202	12/31/2023
NOTE 4 0	12,643,000	$13,319	12/31/2023
IONS	149,338	$7,555	12/31/2023
Northern Trust Corp	687,986	$34,805	12/31/2023
IONS	687,986	$34,805	12/31/2023
Barclays PLC		$34,638	12/31/2023
IONS	644,508	$32,606	12/31/2023
Put	55,000	$2,782	12/31/2023
Call	55,000	$2,782	12/31/2023
BOND	1,926,000	$2,032	12/31/2023
TENOR CAPITAL MANAGEMENT Co. L.P.		$33,784	12/31/2023
NOTE 4 0	32,000,000	$33,784	12/31/2023
BNP Paribas Arbitrage SA		$33,737	12/31/2023
IONS	354,955	$17,957	12/31/2023
Bond	15,000,000	$15,780	12/31/2023
CSS LLC IL		$33,726	12/31/2023
NOTE 4 0	31,931,000	$33,726	12/31/2023
Bank of New York Mellon Corp		$33,275	12/31/2023
IONS	641,063	$32,431	12/31/2023
NOTE	800,000	$844	12/31/2023
Candriam Luxembourg S.C.A.	629,067	$31,826	12/31/2023
IONS	629,067	$31,826	12/31/2023
AXA S.A.		$30,490	12/31/2023
IONS	464,741	$23,511	12/31/2023
NOTE 4 0	6,600,000	$6,979	12/31/2023
Nuveen Asset Management LLC		$26,503	12/31/2023
IONS	324,006	$16,391	12/31/2023
NOTE 4 0	9,612,000	$10,112	12/31/2023
Jacobs Levy Equity Management Inc.	509,533	$25,777	12/31/2023
IONS	509,533	$25,777	12/31/2023
Nomura Holdings Inc.	489,189	$24,748	12/31/2023
IONS	489,189	$24,748	12/31/2023
Pinnacle Associates Ltd.		$23,487	12/31/2023
IONS	458,979	$23,220	12/31/2023
NOTE 0	280,000	$267	12/31/2023
Bank of America Corp DE	455,078	$23,022	12/31/2023
IONS	455,078	$23,022	12/31/2023
DeepCurrents Investment Group LLC		$21,105	12/31/2023
NOTE 4 0	20,000,000	$21,105	12/31/2023
Goldman Sachs Group Inc.		$19,294	12/31/2023
IONS	381,382	$19,294	12/31/2023
Put	30,000	$1,518	12/31/2023
Call	30,000	$1,518	12/31/2023
Calamos Advisors LLC		$18,808	12/31/2023
NOTE 4 0	17,004,000	$17,979	12/31/2023
IONS	16,379	$829	12/31/2023
Groupama Asset Managment	357,036	$18,068	12/31/2023
IONS	357,036	$18,068	12/31/2023
First Turn Management LLC	356,679	$18,044	12/31/2023
IONS	356,679	$18,044	12/31/2023
BNP PARIBAS ASSET MANAGEMENT Holding S.A.	339,667	$17,184	12/31/2023
IONS	339,667	$17,184	12/31/2023
Susquehanna International Group LLP		$16,500	12/31/2023
Call	428,700	$21,688	12/31/2023
Put	156,700	$7,927	12/31/2023
IONS	54,133	$2,739	12/31/2023
Eversept Partners LP	324,654	$16,424	12/31/2023
IONS	324,654	$16,424	12/31/2023
Schonfeld Strategic Advisors LLC	313,274	$15,849	12/31/2023
IONS	313,274	$15,849	12/31/2023
C WorldWide Group Holding A S	300,000	$15,177	12/31/2023
IONS	300,000	$15,177	12/31/2023
Baillie Gifford & Co.	298,483	$15,100	12/31/2023
IONS	298,483	$15,100	12/31/2023
Amundi	272,650	$14,418	12/31/2023
IONS	272,650	$14,418	12/31/2023
Liontrust Investment Partners LLP	283,981	$14,367	12/31/2023
IONS	283,981	$14,367	12/31/2023
Verition Fund Management LLC		$13,989	12/31/2023
IONS	142,854	$7,227	12/31/2023
NOTE4 0	6,397	$6,762	12/31/2023
CI Private Wealth LLC	267,312	$13,523	12/31/2023
IONS	267,312	$13,523	12/31/2023
Voloridge Investment Management LLC	264,121	$13,362	12/31/2023
IONS	264,121	$13,362	12/31/2023
The Manufacturers Life Insurance Company	260,702	$13,189	12/31/2023
IONS	260,702	$13,189	12/31/2023
Alliancebernstein L.P.	257,320	$13,018	12/31/2023
IONS	257,320	$13,018	12/31/2023
Swiss National Bank	254,300	$12,865	12/31/2023
IONS	254,300	$12,865	12/31/2023
Nikko Asset Management Americas Inc.	252,459	$12,757	12/31/2023
IONS	252,459	$12,757	12/31/2023
Stifel Financial Corp	246,029	$12,447	12/31/2023
IONS	246,029	$12,447	12/31/2023
Jefferies Financial Group Inc.		$12,224	12/31/2023
IONS	202,300	$10,234	12/31/2023
NOTE 4 0	1,882,000	$1,990	12/31/2023
Assenagon Asset Management S.A.	271,263	$11,759	03/31/2024
IONS	271,263	$11,759	03/31/2024
Shenkman Capital Management Inc.		$11,720	12/31/2023
NOTE 4 0	10,933,000	$11,720	12/31/2023
Kennedy Capital Management Inc.	228,425	$11,556	12/31/2023
IONS	228,425	$11,556	12/31/2023
Privium Fund Management B.V.	217,493	$11,499	12/31/2023
IONS	217,493	$11,499	12/31/2023
Bank of Montreal Can	223,389	$11,310	12/31/2023
IONS	223,389	$11,310	12/31/2023
Parkman Healthcare Partners LLC	211,400	$10,695	12/31/2023
IONS	211,400	$10,695	12/31/2023
Invesco Ltd.		$10,692	12/31/2023
IONS	205,901	$10,417	12/31/2023
NOTE 4 0	261,000	$275	12/31/2023
California Public Employees Retirement System	209,436	$10,595	12/31/2023
IONS	209,436	$10,595	12/31/2023
Altrinsic Global Advisors LLC	209,152	$10,581	12/31/2023
IONS	209,152	$10,581	12/31/2023
Tang Capital Management LLC	200,000	$10,118	12/31/2023
IONS	200,000	$10,118	12/31/2023
Cubist Systematic Strategies LLC	199,477	$10,092	12/31/2023
IONS	199,477	$10,092	12/31/2023
Rhumbline Advisers	199,416	$10,088	12/31/2023
IONS	199,416	$10,088	12/31/2023
Credit Suisse AG		$10,040	12/31/2023
IONS	189,722	$9,598	12/31/2023
NOTE 4 0	461,000	$442	12/31/2023
UBS Asset Management Americas Inc.		$9,953	12/31/2023
IONS	186,327	$9,426	12/31/2023
CONV BD US	500,000	$527	12/31/2023
Sicart Associates LLC	194,293	$9,829	12/31/2023
IONS	194,293	$9,829	12/31/2023
Superstring Capital Management LP	189,618	$9,593	12/31/2023
IONS	189,618	$9,593	12/31/2023
Sumitomo Mitsui Trust Holdings Inc.	220,261	$9,548	03/31/2024
IONS	220,261	$9,548	03/31/2024
Rafferty Asset Management LLC	184,396	$9,329	12/31/2023
IONS	184,396	$9,329	12/31/2023
Deutsche Bank AG		$9,012	12/31/2023
NOTE 4 0	8,500,000	$8,942	12/31/2023
IONS	35,702	$1,806	12/31/2023
Put	1,650,000	$1,736	12/31/2023
Russell Investments Group Ltd.		$8,676	12/31/2023
IONS	157,802	$7,983	12/31/2023
Sovereign Corporate	655,000	$693	12/31/2023
Susquehanna Portfolio Strategies LLC	169,678	$8,584	12/31/2023
IONS	169,678	$8,584	12/31/2023
Schroder Investment Management Group		$8,544	12/31/2023
NOTE4 0	5,600,000	$5,891	12/31/2023
IONS	43,000	$2,175	12/31/2023
NOTE 0	500,000	$478	12/31/2023
Tocqueville Asset Management L.P.	159,780	$8,083	12/31/2023
IONS	159,780	$8,083	12/31/2023
UBS Group AG		$8,082	12/31/2023
IONS	159,739	$8,081	12/31/2023
NOTE 4 0	1,000	$1	12/31/2023
Lombard Odier Asset Management Europe Ltd		$7,950	12/31/2023
NOTE 4 0	7,580,000	$7,950	12/31/2023
Legal & General Group Plc	155,348	$7,859	12/31/2023
IONS	155,348	$7,859	12/31/2023
Man Group plc		$7,715	12/31/2023
IONS	78,475	$3,970	12/31/2023
NOTE 4 0	3,550,000	$3,745	12/31/2023
State Board of Administration of Florida Retirement System	151,055	$7,642	12/31/2023
IONS	151,055	$7,642	12/31/2023
BLB&B Advisors LLC	147,100	$7,442	12/31/2023
IONS	147,100	$7,442	12/31/2023
Hudson Bay Capital Management LP	145,000	$7,336	12/31/2023
IONS	145,000	$7,336	12/31/2023
Sector Gamma AS	145,012	$7,336	12/31/2023
IONS	145,012	$7,336	12/31/2023
California State Teachers Retirement System	138,532	$7,008	12/31/2023
IONS	138,532	$7,008	12/31/2023
Standard Life Aberdeen plc	136,419	$6,901	12/31/2023
IONS	136,419	$6,901	12/31/2023
DZ BANK AG Deutsche Zentral Genossenschafts Bank Frankfurt am Main		$6,868	12/31/2023
NOTE 4 0	4,250,000	$4,483	12/31/2023
NOTE 0	2,500,000	$2,385	12/31/2023
Senator Investment Group LP	135,000	$6,830	12/31/2023
IONS	135,000	$6,830	12/31/2023
SSI Investment Management LLC		$6,811	12/31/2023
NOTE 4 0	6,474,000	$6,811	12/31/2023
Marshall Wace LLP	133,549	$6,756	12/31/2023
IONS	133,549	$6,756	12/31/2023
Envestnet Asset Management Inc.	133,484	$6,753	12/31/2023
IONS	133,484	$6,753	12/31/2023
Citigroup Inc.		$6,749	12/31/2023
IONS	100,245	$5,071	12/31/2023
NOTE 0	1,754,000	$1,678	12/31/2023
Connor Clark & Lunn Investment Management Ltd.	127,954	$6,473	12/31/2023
IONS	127,954	$6,473	12/31/2023
Dimensional Fund Advisors LP	125,217	$6,335	12/31/2023
IONS	125,217	$6,335	12/31/2023
Granite Investment Partners LLC	119,946	$6,068	12/31/2023
IONS	119,946	$6,068	12/31/2023
D. E. Shaw & Co. Inc.	119,158	$6,028	12/31/2023
IONS	119,158	$6,028	12/31/2023
Walleye Capital LLC		$5,922	12/31/2023
NOTE 4 0	6,000,000	$6,342	12/31/2023
Put	8,600	$435	12/31/2023
Call	300	$15	12/31/2023
Trexquant Investment LP	112,987	$5,716	12/31/2023
IONS	112,987	$5,716	12/31/2023
Renaissance Technologies LLC	112,414	$5,687	12/31/2023
IONS	112,414	$5,687	12/31/2023
Braidwell LP		$5,539	12/31/2023
NOTE 4 0	5,240,000	$5,539	12/31/2023
Parkwood LLC	108,554	$5,492	12/31/2023
IONS	108,554	$5,492	12/31/2023
Peregrine Capital Management LLC	107,824	$5,455	12/31/2023
IONS	107,824	$5,455	12/31/2023
New York State Common Retirement Fund	105,329	$5,329	12/31/2023
IONS	105,329	$5,329	12/31/2023
Penn Mutual Asset Management LLC		$5,275	12/31/2023
NOTE 0	5,512,000	$5,275	12/31/2023
State of Wisconsin Investment Board	103,565	$5,239	12/31/2023
IONS	103,565	$5,239	12/31/2023
Jane Street Group LLC		$5,219	12/31/2023
IONS	154,164	$7,799	12/31/2023
Put	73,500	$3,718	12/31/2023
Call	22,500	$1,138	12/31/2023
Raymond James & Associates	112,554	$4,879	03/31/2024
IONS	112,554	$4,879	03/31/2024
LPL Financial LLC	87,299	$4,416	12/31/2023
IONS	87,299	$4,416	12/31/2023
DAVENPORT & Co LLC	86,328	$4,367	12/31/2023
IONS	86,328	$4,367	12/31/2023
DekaBank Deutsche Girozentrale	93,807	$4,162	03/31/2024
IONS	93,807	$4,162	03/31/2024
State of New Jersey Common Pension Fund D	81,847	$4,141	12/31/2023
IONS	81,847	$4,141	12/31/2023
Voya Investment Management LLC	76,911	$3,891	12/31/2023
IONS	76,911	$3,891	12/31/2023
Sei Investments Co.		$3,822	12/31/2023
IONS	70,173	$3,550	12/31/2023
NOTE 4 0	259,000	$272	12/31/2023
Aigen Investment Management LP	73,720	$3,729	12/31/2023
IONS	73,720	$3,729	12/31/2023
Cinctive Capital Management LP	73,256	$3,706	12/31/2023
IONS	73,256	$3,706	12/31/2023
Linden Advisors LP		$3,432	12/31/2023
SDBCV	3,250,000	$3,432	12/31/2023
Commerce Bank	67,017	$3,390	12/31/2023
IONS	67,017	$3,390	12/31/2023
Van ECK Associates Corp	65,831	$3,331	12/31/2023
IONS	65,831	$3,331	12/31/2023
Treasurer of the State of North Carolina	63,152	$3,195	12/31/2023
IONS	63,152	$3,195	12/31/2023
Lisanti Capital Growth LLC	62,415	$3,158	12/31/2023
IONS	62,415	$3,158	12/31/2023
Jump Financial LLC	61,739	$3,123	12/31/2023
IONS	61,739	$3,123	12/31/2023
Janus Henderson Group PLC	59,703	$3,019	12/31/2023
IONS	59,703	$3,019	12/31/2023
Skandinaviska Enskilda Banken AB publ	59,626	$3,019	12/31/2023
IONS	59,626	$3,019	12/31/2023
Public Employees Retirement System of Ohio	59,630	$3,017	12/31/2023
IONS	59,630	$3,017	12/31/2023
Squarepoint Ops LLC	59,204	$2,995	12/31/2023
IONS	59,204	$2,995	12/31/2023
HighTower Advisors LLC		$2,921	12/31/2023
NOTE 0	2,453,000	$2,361	12/31/2023
IONS	11,086	$560	12/31/2023
HighVista Strategies LLC	57,348	$2,901	12/31/2023
IONS	57,348	$2,901	12/31/2023
Nicola Wealth Management LTD.	56,000	$2,833	12/31/2023
IONS	56,000	$2,833	12/31/2023
Cowen AND Company LLC	51,415	$2,601	12/31/2023
IONS	51,415	$2,601	12/31/2023
Palisade Capital Management LLC NJ		$2,469	12/31/2023
NOTE 0	2,589,000	$2,469	12/31/2023
Private Advisor Group LLC	48,807	$2,469	12/31/2023
IONS	48,807	$2,469	12/31/2023
Ensign Peak Advisors Inc	46,310	$2,343	12/31/2023
IONS	46,310	$2,343	12/31/2023
NJ State Employees Deferred Compensation Plan	42,000	$2,125	12/31/2023
IONS	42,000	$2,125	12/31/2023
Great West Life Assurance Co. Can	40,781	$2,048	12/31/2023
IONS	40,781	$2,048	12/31/2023
Capital Counsel LLC NY	40,080	$2,028	12/31/2023
IONS	40,080	$2,028	12/31/2023
Comerica Bank		$2,005	12/31/2023
IONS	39,614	$2,004	12/31/2023
COMMON	1,000	$1	12/31/2023
Arizona State Retirement System	36,059	$1,824	12/31/2023
IONS	36,059	$1,824	12/31/2023
Guggenheim Capital LLC	33,151	$1,677	12/31/2023
IONS	33,151	$1,677	12/31/2023
Grandfield & Dodd LLC	33,104	$1,675	12/31/2023
IONS	33,104	$1,675	12/31/2023
Estate Counselors LLC	32,800	$1,659	12/31/2023
IONS	32,800	$1,659	12/31/2023
Oaktree Capital Management LP		$1,586	12/31/2023
CONVERTIBLE BOND	1,500,000	$1,586	12/31/2023
Principal Financial Group Inc.	31,139	$1,575	12/31/2023
IONS	31,139	$1,575	12/31/2023
Nicholas Investment Partners LP	30,445	$1,540	12/31/2023
IONS	30,445	$1,540	12/31/2023
Teacher Retirement System of Texas	29,844	$1,510	12/31/2023
IONS	29,844	$1,510	12/31/2023
Twinbeech Capital LP	29,729	$1,504	12/31/2023
IONS	29,729	$1,504	12/31/2023
Zurcher Kantonalbank Zurich Cantonalbank	29,440	$1,489	12/31/2023
IONS	29,440	$1,489	12/31/2023
Profund Advisors LLC	29,073	$1,471	12/31/2023
IONS	29,073	$1,471	12/31/2023
Engineers Gate Manager LP	28,877	$1,461	12/31/2023
IONS	28,877	$1,461	12/31/2023
UBS Oconnor LLC	28,624	$1,448	12/31/2023
IONS	28,624	$1,448	12/31/2023
Janney Montgomery Scott LLC	28,379	$1,435	12/31/2023
IONS	28,379	$1,435	12/31/2023
Victory Capital Management Inc.	27,793	$1,406	12/31/2023
IONS	27,793	$1,406	12/31/2023
Handelsbanken Fonder AB	27,011	$1,366	12/31/2023
IONS	27,011	$1,366	12/31/2023
Ameriprise Financial Inc.	25,625	$1,296	12/31/2023
IONS	25,625	$1,296	12/31/2023
Creative Planning	25,299	$1,280	12/31/2023
IONS	25,299	$1,280	12/31/2023
Strs Ohio	24,779	$1,253	12/31/2023
IONS	24,779	$1,253	12/31/2023
Kohlberg Kravis Roberts & Co. L.P.		$1,233	12/31/2023
NOTE 4 0	700,000	$740	12/31/2023
NOTE 0	510,000	$493	12/31/2023
HealthInvest Partners AB	24,243	$1,226	12/31/2023
IONS	24,243	$1,226	12/31/2023
Fred Alger Management LLC	24,054	$1,217	12/31/2023
IONS	24,054	$1,217	12/31/2023
ExodusPoint Capital Management LP	23,484	$1,188	12/31/2023
IONS	23,484	$1,188	12/31/2023
Commonwealth Equity Services LLC	21,462	$1,086	12/31/2023
IONS	21,462	$1,086	12/31/2023
Mariner LLC	20,672	$1,046	12/31/2023
IONS	20,672	$1,046	12/31/2023
Point72 Hong Kong Ltd	20,015	$1,013	12/31/2023
IONS	20,015	$1,013	12/31/2023
Advisor Group Holdings Inc.	18,910	$956	12/31/2023
IONS	18,910	$956	12/31/2023
Algert Global LLC	17,412	$881	12/31/2023
IONS	17,412	$881	12/31/2023
Natixis Advisors L.P.	17,313	$875	12/31/2023
IONS	17,313	$875	12/31/2023
Xponance Inc.	16,693	$844	12/31/2023
IONS	16,693	$844	12/31/2023
Blair William & Co. IL	16,628	$841	12/31/2023
IONS	16,628	$841	12/31/2023
China Universal Asset Management Co. Ltd.	16,598	$840	12/31/2023
IONS	16,598	$840	12/31/2023
Public Employees Retirement Association of Colorado	16,574	$838	12/31/2023
IONS	16,574	$838	12/31/2023
Two Sigma Securities LLC		$779	12/31/2023
IONS	15,404	$779	12/31/2023
Put	4,700	$238	12/31/2023
Call	4,700	$238	12/31/2023
NBT Bank N A NY	17,050	$739	03/31/2024
IONS	17,050	$739	03/31/2024
Tanaka Capital Management Inc.	14,612	$739	12/31/2023
IONS	14,612	$739	12/31/2023
Friedenthal Financial	14,225	$720	12/31/2023
IONS	14,225	$720	12/31/2023
Teachers Retirement System of The State of Kentucky	14,118	$714	12/31/2023
IONS	14,118	$714	12/31/2023
Bard Financial Services Inc.	14,100	$713	12/31/2023
IONS	14,100	$713	12/31/2023
Neuberger Berman Group LLC	13,998	$708	12/31/2023
IONS	13,998	$708	12/31/2023
Simplicity Wealth LLC	16,229	$704	03/31/2024
IONS	16,229	$704	03/31/2024
Franklin Resources Inc.	13,705	$693	12/31/2023
IONS	13,705	$693	12/31/2023
North Star Asset Management Inc.	13,650	$691	12/31/2023
IONS	13,650	$691	12/31/2023
Martingale Asset Management L P	13,312	$673	12/31/2023
IONS	13,312	$673	12/31/2023
American Century Companies Inc.	13,216	$669	12/31/2023
IONS	13,216	$669	12/31/2023
GTS Securities LLC		$668	12/31/2023
Call	13,200	$668	12/31/2023
Oppenheimer Asset Management Inc.		$657	12/31/2023
IONS	10,549	$534	12/31/2023
NOTE 4 0	117,000	$123	12/31/2023
Chartwell Investment Partners LLC	12,982	$657	12/31/2023
IONS	12,982	$657	12/31/2023
Quantbot Technologies LP	12,703	$643	12/31/2023
IONS	12,703	$643	12/31/2023
Graham Capital Management L.P.	12,525	$634	12/31/2023
IONS	12,525	$634	12/31/2023
Horizon Kinetics Asset Management LLC	12,476	$631	12/31/2023
IONS	12,476	$631	12/31/2023
Granite Bay Wealth Management LLC	13,579	$626	12/31/2023
IONS	13,579	$626	12/31/2023
Sawtooth Solutions LLC	12,239	$619	12/31/2023
IONS	12,239	$619	12/31/2023
Bleakley Financial Group LLC	12,239	$619	12/31/2023
IONS	12,239	$619	12/31/2023
Pathstone Holdings LLC	11,882	$611	12/31/2023
IONS	11,882	$611	12/31/2023
Raymond James Financial Services Advisors Inc.		$605	03/31/2024
IONS	13,508	$586	03/31/2024
NOTE 0	20,000	$19	03/31/2024
US Bancorp DE	11,935	$604	12/31/2023
IONS	11,935	$604	12/31/2023
GSA Capital Partners LLP	11,680	$591	12/31/2023
IONS	11,680	$591	12/31/2023
Corton Capital Inc.	11,476	$581	12/31/2023
IONS	11,476	$581	12/31/2023
Northwestern Mutual Wealth Management Co.	11,146	$564	12/31/2023
IONS	11,146	$564	12/31/2023
Plancorp LLC	11,155	$564	12/31/2023
IONS	11,155	$564	12/31/2023
Captrust Financial Advisors	10,108	$511	12/31/2023
IONS	10,108	$511	12/31/2023
PEAK6 Investments LLC		$505	12/31/2023
IONS	9,001	$455	12/31/2023
Call	4,000	$202	12/31/2023
Put	3,000	$152	12/31/2023
Point72 Middle East FZE	9,983	$505	12/31/2023
IONS	9,983	$505	12/31/2023
Truist Financial Corp	9,965	$504	12/31/2023
IONS	9,965	$504	12/31/2023
E Fund Management Co. Ltd.	9,865	$499	12/31/2023
IONS	9,865	$499	12/31/2023
Nicollet Investment Management Inc.	9,776	$495	12/31/2023
IONS	9,776	$495	12/31/2023
Teza Capital Management LLC	9,733	$492	12/31/2023
IONS	9,733	$492	12/31/2023
Brown Advisory Inc.	11,122	$482	03/31/2024
IONS	11,122	$482	03/31/2024
Fox Run Management L.L.C.	9,271	$469	12/31/2023
IONS	9,271	$469	12/31/2023
ProShare Advisors LLC	9,167	$464	12/31/2023
IONS	9,167	$464	12/31/2023
Bank Julius Baer & Co. Ltd Zurich	9,050	$458	12/31/2023
IONS	9,050	$458	12/31/2023
Maryland State Retirement & Pension System	10,950	$451	03/31/2024
IONS	10,950	$451	03/31/2024
NEOS Investment Management LLC	8,906	$451	12/31/2023
IONS	8,906	$451	12/31/2023
Stephens Inc. AR		$437	12/31/2023
IONS	7,955	$402	12/31/2023
NOTE 4 0	33,000	$35	12/31/2023
Midwest Professional Planners LTD.	8,519	$431	12/31/2023
IONS	8,519	$431	12/31/2023
AtonRa Partners	8,396	$425	12/31/2023
IONS	8,396	$425	12/31/2023
The PNC Financial Services Group Inc.	8,378	$424	12/31/2023
IONS	8,378	$424	12/31/2023
JustInvest LLC	8,342	$422	12/31/2023
IONS	8,342	$422	12/31/2023
Fifth Third Bancorp	9,633	$418	03/31/2024
IONS	9,633	$418	03/31/2024
Vontobel Holding Ltd.	8,210	$415	12/31/2023
IONS	8,210	$415	12/31/2023
Cambridge Investment Research Advisors Inc.	9,312	$404	03/31/2024
IONS	9,312	$404	03/31/2024
Utah Retirement Systems	7,900	$400	12/31/2023
IONS	7,900	$400	12/31/2023
Amalgamated Bank	9,203	$399	03/31/2024
IONS	9,203	$399	03/31/2024
MetLife Investment Management LLC	7,817	$395	12/31/2023
IONS	7,817	$395	12/31/2023
Wrapmanager Inc.	7,404	$375	12/31/2023
IONS	7,404	$375	12/31/2023
Gotham Asset Management LLC	6,989	$354	12/31/2023
IONS	6,989	$354	12/31/2023
Castle Rock Wealth Management LLC	6,972	$352	12/31/2023
IONS	6,972	$352	12/31/2023
KBC Group NV		$346	12/31/2023
NOTE 4 0	200,000	$211	12/31/2023
IONS	2,669	$135	12/31/2023
Sherbrooke Park Advisers LLC	6,789	$343	12/31/2023
IONS	6,789	$343	12/31/2023
Baird Financial Group Inc.	6,689	$338	12/31/2023
IONS	6,689	$338	12/31/2023
International Assets Investment Management LLC	7,607	$334	03/31/2024
IONS	7,607	$334	03/31/2024
Virtus ETF Advisers LLC	6,548	$331	12/31/2023
IONS	6,548	$331	12/31/2023
Sectoral Asset Management Inc	6,480	$328	12/31/2023
IONS	6,480	$328	12/31/2023
Aquatic Capital Management LLC	6,400	$324	12/31/2023
IONS	6,400	$324	12/31/2023
SG Americas Securities LLC	6,129	$310	12/31/2023
IONS	6,129	$310	12/31/2023
Weiss Asset Management LP	5,874	$297	12/31/2023
IONS	5,874	$297	12/31/2023
Regions Financial Corp	6,785	$294	03/31/2024
IONS	6,785	$294	03/31/2024
Kapitalo Investimentos Ltda	5,714	$289	12/31/2023
IONS	5,714	$289	12/31/2023
Massachusetts Financial Services Co. MA	5,592	$283	12/31/2023
IONS	5,592	$283	12/31/2023
CI Investments Inc.	5,588	$283	12/31/2023
IONS	5,588	$283	12/31/2023
Perkins Capital Management Inc.	5,550	$281	12/31/2023
IONS	5,550	$281	12/31/2023
Capital Wealth Planning LLC	5,408	$274	12/31/2023
IONS	5,408	$274	12/31/2023
Dynamic Technology Lab Private Ltd	5,273	$267	12/31/2023
IONS	5,273	$267	12/31/2023
M&T Bank Corp	5,188	$263	12/31/2023
IONS	5,188	$263	12/31/2023
Buckingham Strategic Wealth LLC	5,170	$262	12/31/2023
IONS	5,170	$262	12/31/2023
Diversified Trust Co	6,015	$261	03/31/2024
IONS	6,015	$261	03/31/2024
Kestra Advisory Services LLC	5,040	$255	12/31/2023
IONS	5,040	$255	12/31/2023
Oracle Alpha Inc.	5,019	$254	12/31/2023
IONS	5,019	$254	12/31/2023
Beaird Harris Wealth Management LLC	5,000	$253	12/31/2023
IONS	5,000	$253	12/31/2023
Vident Advisory LLC	4,930	$249	12/31/2023
IONS	4,930	$249	12/31/2023
Prospera Financial Services Inc	4,698	$238	12/31/2023
IONS	4,698	$238	12/31/2023
Mercer Global Advisors Inc. ADV	4,676	$237	12/31/2023
IONS	4,676	$237	12/31/2023
Mitchell & Pahl Private Wealth LLC	4,617	$234	12/31/2023
IONS	4,617	$234	12/31/2023
Handelsinvest Investeringsforvaltning	5,287	$229	03/31/2024
IONS	5,287	$229	03/31/2024
MML Investors Services LLC	4,324	$219	12/31/2023
IONS	4,324	$219	12/31/2023
Level Four Advisory Services LLC	4,302	$218	12/31/2023
IONS	4,302	$218	12/31/2023
Prudential Financial Inc.	4,269	$216	12/31/2023
IONS	4,269	$216	12/31/2023
AQR Capital Management LLC	4,300	$214	12/31/2023
IONS	4,300	$214	12/31/2023
Checchi Capital Advisers LLC	4,234	$214	12/31/2023
IONS	4,234	$214	12/31/2023
Berkshire Asset Management LLC PA	4,180	$211	12/31/2023
IONS	4,180	$211	12/31/2023
Cetera Advisor Networks LLC	4,081	$206	12/31/2023
IONS	4,081	$206	12/31/2023
CIBC Asset Management Inc	4,002	$202	12/31/2023
IONS	4,002	$202	12/31/2023
Mitsubishi UFJ Kokusai Asset Management Co. Ltd.	3,693	$191	12/31/2023
IONS	3,693	$191	12/31/2023
Tower Research Capital LLC TRC	3,360	$170	12/31/2023
IONS	3,360	$170	12/31/2023
Wolverine Trading LLC		$146	12/31/2023
Put	13,800	$698	12/31/2023
IONS	9,495	$480	12/31/2023
Call	7,200	$364	12/31/2023
Natixis	2,878	$146	12/31/2023
IONS	2,878	$146	12/31/2023
Calamos Wealth Management LLC		$142	12/31/2023
NOTE 4 0	134,000	$142	12/31/2023
Icon Wealth Advisors LLC	2,537	$128	12/31/2023
IONS	2,537	$128	12/31/2023
American International Group Inc.	2,237	$113	12/31/2023
IONS	2,237	$113	12/31/2023
GWM Advisors LLC	2,088	$106	12/31/2023
IONS	2,088	$106	12/31/2023
CWM LLC	2,228	$97	03/31/2024
IONS	2,228	$97	03/31/2024
Horizon Investments LLC	1,927	$97	12/31/2023
IONS	1,927	$97	12/31/2023
Twin Lakes Capital Management LLC	1,500	$76	12/31/2023
IONS	1,500	$76	12/31/2023
Itau Unibanco Holding S.A.	1,429	$72	12/31/2023
IONS	1,429	$72	12/31/2023
IFP Advisors Inc	1,070	$54	12/31/2023
IONS	1,070	$54	12/31/2023
Harbour Investments Inc.	900	$46	12/31/2023
IONS	900	$46	12/31/2023
Steward Partners Investment Advisory LLC		$45	12/31/2023
IONS	481	$24	12/31/2023
NOTE	22,000	$21	12/31/2023
Sunbelt Securities Inc.	1,014	$44	03/31/2024
IONS	1,014	$44	03/31/2024
EntryPoint Capital LLC	878	$44	12/31/2023
IONS	878	$44	12/31/2023
Archer Investment Corp	850	$43	12/31/2023
IONS	850	$43	12/31/2023
Allworth Financial LP	776	$39	12/31/2023
IONS	776	$39	12/31/2023
Institutional & Family Asset Management LLC	729	$37	12/31/2023
IONS	729	$37	12/31/2023
Glassman Wealth Services	686	$35	12/31/2023
IONS	686	$35	12/31/2023
Quadrant Capital Group LLC	671	$34	12/31/2023
IONS	671	$34	12/31/2023
Daiwa Securities Group Inc.	587	$30	12/31/2023
IONS	587	$30	12/31/2023
Laurel Wealth Advisors LLC	600	$30	12/31/2023
IONS	600	$30	12/31/2023
Mather Group LLC.	671	$29	03/31/2024
IONS	671	$29	03/31/2024
Parallel Advisors LLC	565	$29	12/31/2023
IONS	565	$29	12/31/2023
Farther Finance Advisors LLC	569	$29	12/31/2023
IONS	569	$29	12/31/2023
GAMMA Investing LLC	612	$27	03/31/2024
IONS	612	$27	03/31/2024
Advisory Services Network LLC	519	$26	12/31/2023
IONS	519	$26	12/31/2023
Clearstead Advisors LLC	495	$25	12/31/2023
IONS	495	$25	12/31/2023
Signaturefd LLC	501	$25	12/31/2023
IONS	501	$25	12/31/2023
Pingora Partners LLC	500	$25	12/31/2023
IONS	500	$25	12/31/2023
Whittier Trust Co.	462	$23	12/31/2023
IONS	462	$23	12/31/2023
Riverview Trust Co	476	$21	03/31/2024
IONS	476	$21	03/31/2024
Global Trust Asset Management LLC	474	$21	03/31/2024
IONS	474	$21	03/31/2024
Lindbrook Capital LLC	393	$20	12/31/2023
IONS	393	$20	12/31/2023
ORG Partners LLC	400	$20	12/31/2023
IONS	400	$20	12/31/2023
Quilter Plc	363	$18	12/31/2023
IONS	363	$18	12/31/2023
AlphaMark Advisors LLC	400	$17	03/31/2024
IONS	400	$17	03/31/2024
Banque Cantonale Vaudoise	400	$17	03/31/2024
IONS	400	$17	03/31/2024
Whittier Trust Co. of Nevada Inc.	341	$17	12/31/2023
IONS	341	$17	12/31/2023
EverSource Wealth Advisors LLC	340	$17	12/31/2023
IONS	340	$17	12/31/2023
Private Trust Co. NA	378	$16	03/31/2024
IONS	378	$16	03/31/2024
Huntington National Bank	289	$15	12/31/2023
IONS	289	$15	12/31/2023
Advisors Asset Management Inc.	303	$15	12/31/2023
IONS	303	$15	12/31/2023
Riggs Asset Managment Co. Inc.	250	$13	12/31/2023
IONS	250	$13	12/31/2023
Washington Trust Advisors Inc.	258	$13	12/31/2023
IONS	258	$13	12/31/2023
Covestor Ltd	243	$12	12/31/2023
IONS	243	$12	12/31/2023
AllSquare Wealth Management LLC	198	$10	12/31/2023
IONS	198	$10	12/31/2023
GPS Wealth Strategies Group LLC	198	$10	12/31/2023
IONS	198	$10	12/31/2023
SYSTM Wealth Solutions LLC	204	$10	12/31/2023
IONS	204	$10	12/31/2023
Quarry LP	200	$10	12/31/2023
IONS	200	$10	12/31/2023
Pacifica Partners Inc.	150	$7	03/31/2024
IONS	150	$7	03/31/2024
Ronald Blue Trust Inc.	137	$7	12/31/2023
IONS	137	$7	12/31/2023
Garner Asset Management Corp	115	$6	12/31/2023
IONS	115	$6	12/31/2023
Cornerstone Planning Group LLC	109	$6	12/31/2023
IONS	109	$6	12/31/2023
Colonial Trust Co SC	120	$6	12/31/2023
IONS	120	$6	12/31/2023
Sachetta LLC	115	$6	12/31/2023
IONS	115	$6	12/31/2023
Spire Wealth Management	125	$5	03/31/2024
IONS	125	$5	03/31/2024
Creekmur Asset Management LLC	100	$5	12/31/2023
IONS	100	$5	12/31/2023
Exchange Traded Concepts LLC	82	$4	03/31/2024
IONS	82	$4	03/31/2024
Global Retirement Partners LLC	94	$4	03/31/2024
IONS	94	$4	03/31/2024
SRS Capital Advisors Inc.	84	$4	12/31/2023
IONS	84	$4	12/31/2023
Bogart Wealth LLC	85	$4	12/31/2023
IONS	85	$4	12/31/2023
Semmax Financial Advisors Inc.	82	$4	12/31/2023
IONS	82	$4	12/31/2023
DAGCO Inc.	80	$4	12/31/2023
IONS	80	$4	12/31/2023
Dynamic Wealth Strategies LLC	80	$4	12/31/2023
IONS	80	$4	12/31/2023
Bell Investment Advisors Inc	71	$4	12/31/2023
IONS	71	$4	12/31/2023
Raleigh Capital Management Inc.	72	$4	12/31/2023
IONS	72	$4	12/31/2023
Massmutual Trust Co. FSB ADV	67	$3	03/31/2024
IONS	67	$3	03/31/2024
Versant Capital Management Inc	59	$3	03/31/2024
IONS	59	$3	03/31/2024
Bessemer Group Inc.	52	$3	12/31/2023
IONS	52	$3	12/31/2023
Parkside Financial Bank & Trust	62	$3	12/31/2023
IONS	62	$3	12/31/2023
Blume Capital Management Inc.	55	$3	12/31/2023
IONS	55	$3	12/31/2023
Rockbridge Investment Management LCC	58	$3	12/31/2023
IONS	58	$3	12/31/2023
Orion Capital Management LLC	38	$2	12/31/2023
IONS	38	$2	12/31/2023
CVA Family Office LLC	30	$1	03/31/2024
IONS	30	$1	03/31/2024
First Pacific Financial	29	$1	03/31/2024
IONS	29	$1	03/31/2024
Rosenberg Matthew Hamilton	20	$1	03/31/2024
IONS	20	$1	03/31/2024
Allspring Global Investments Holdings LLC	16	$1	03/31/2024
IONS	16	$1	03/31/2024
Proequities Inc.		$1	12/31/2023
IONS	19	$1	12/31/2023
Put	0	$0	12/31/2023
Call	0	$0	12/31/2023
NOTE 4 0	0	$0	12/31/2023
NOTE 0	0	$0	12/31/2023
Focused Wealth Management Inc	16	$1	12/31/2023
IONS	16	$1	12/31/2023
Front Row Advisors LLC	20	$1	12/31/2023
IONS	20	$1	12/31/2023
Retirement Group LLC	11	$1	12/31/2023
IONS	11	$1	12/31/2023
Avion Wealth	25	$1	12/31/2023
IONS	25	$1	12/31/2023
Key Financial Inc	19	$1	12/31/2023
IONS	19	$1	12/31/2023
Quent Capital LLC	21	$1	12/31/2023
IONS	21	$1	12/31/2023
Private Wealth Management Group LLC	10	$1	12/31/2023
IONS	10	$1	12/31/2023
Capital Advisors Ltd. LLC	7	$0	03/31/2024
IONS	7	$0	03/31/2024
Nomura Asset Management Co. Ltd.	0	$0	12/31/2023
IONS	0	$0	12/31/2023
Fairfield Bush & CO.	4	$0	12/31/2023
IONS	4	$0	12/31/2023
Assetmark Inc.	7	$0	12/31/2023
IONS	7	$0	12/31/2023
Manchester Capital Management LLC	5	$0	12/31/2023
IONS	5	$0	12/31/2023
JNBA Financial Advisors	7	$0	12/31/2023
IONS	7	$0	12/31/2023
FWL Investment Management LLC	0	$0	12/31/2023
IONS	0	$0	12/31/2023
Tucker Asset Management LLC	3	$0	12/31/2023
IONS	3	$0	12/31/2023
Quest Partners LLC	1	$0	12/31/2023
IONS	1	$0	12/31/2023
Cape Investment Advisory Inc.	2	$0	12/31/2023
IONS	2	$0	12/31/2023
Group One Trading L.P.		$-85	12/31/2023
Put	4,800	$243	12/31/2023
Call	2,100	$106	12/31/2023
IONS	1,018	$52	12/31/2023
Walleye Trading LLC		$-211	12/31/2023
Put	6,300	$319	12/31/2023
Call	2,000	$101	12/31/2023
IONS	148	$7	12/31/2023
Torno Capital LLC		$-633	12/31/2023
Put	15,000	$759	12/31/2023
IONS	2,500	$126	12/31/2023
Simplex Trading LLC		$-1,329	12/31/2023
Put	52,100	$2,635	12/31/2023
Call	16,300	$824	12/31/2023
IONS	9,545	$482	12/31/2023
Twin Tree Management LP	21,000	$-7,933	12/31/2023
Put	177,800	$8,995	12/31/2023
Call	21,000	$1,062	12/31/2023

See Summary: Institutional Holders of IONS
See Details: Top 10 Hedge Funds Holding IONS
Also See: IONS Holdings Changes

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