All Stocks Held By Sphera Funds Management LTD.

As of 12/31/2023, we find all stocks held by Sphera Funds Management LTD. to be as follows, presented in the table below with each row detailing each Sphera Funds Management LTD. position, ordered by largest to smallest position size. The all-stocks-held-by-Sphera Funds Management LTD. table shows the entity held in the first column (click any entity to explore other funds holding positions), the share amount held, the share count change between the last two reporting periods, and finally the position size for all stocks held by Sphera Funds Management LTD. as of the latest filing.

Entity	Amount	Change 09/30/2023 to 12/31/2023	Position Size ($ in 1000's)
TEVA PHARMACEUTICAL INDS LTD			$39,182
TEVA	2,469,100	+1,869,100	$25,777
Call	1,284,000	-3,729,800	$13,405
SANOFI	499,515	UNCH	$24,841
SNY	499,515	UNCH	$24,841
CYTOKINETICS INC			$21,676
CYTK	223,820	-10,113	$18,687
Call	35,800	-29,200	$2,989
NOVA LTD	132,000	+132,000	$18,135
NVMI	132,000	+132,000	$18,135
CELLDEX THERAPEUTICS INC NEW			$17,107
CLDX	315,644	+135,644	$12,518
Call	115,700	+15,700	$4,589
SYNDAX PHARMACEUTICALS INC	772,964	-97	$16,704
SNDX	772,964	-97	$16,704
TOWER SEMICONDUCTOR LTD	528,300	+58,726	$16,124
TSEM	528,300	+58,726	$16,124
NICE LTD	67,718	-74,764	$13,510
NICE	67,718	+30,236	$13,510
MERCK & CO INC	123,600	UNCH	$13,475
MRK	123,600	UNCH	$13,475
JOHNSON & JOHNSON	79,831	-15,000	$12,513
JNJ	79,831	-15,000	$12,513
META PLATFORMS INC	34,303	+19,083	$12,142
META	34,303	+19,083	$12,142
ASTRAZENECA PLC	180,060	-105,000	$12,127
AZN	180,060	-105,000	$12,127
BIOGEN INC	46,346	+20,500	$11,993
BIIB	46,346	+20,500	$11,993
BRIDGEBIO PHARMA INC	282,146	-63,391	$11,390
BBIO	282,146	-63,391	$11,390
ALNYLAM PHARMACEUTICALS INC			$10,763
ALNY	36,230	+129	$6,935
Call	20,000	+20,000	$3,828
GLOBAL E ONLINE LTD	269,794	+269,794	$10,692
GLBE	269,794	+269,794	$10,692
FUSION PHARMACEUTICALS INC	1,085,639	-268,619	$10,433
FUSN	1,085,639	-268,619	$10,433
KURA ONCOLOGY INC	703,287	UNCH	$10,113
KURA	703,287	UNCH	$10,113
NOVO NORDISK A S	93,080	UNCH	$9,629
NVO	93,080	UNCH	$9,629
ULTRAGENYX PHARMACEUTICAL IN	201,044	-58,091	$9,614
RARE	201,044	-58,091	$9,614
MICROSOFT CORP	23,848	-10,594	$8,968
MSFT	23,848	-10,594	$8,968
ASTRIA THERAPEUTICS INC	1,151,145	+570,546	$8,841
ATXS	1,151,145	+570,546	$8,841
ENPHASE ENERGY INC			$8,840
ENPH	34,800	+34,800	$4,598
Call	32,100	+32,100	$4,242
INHIBRX INC	226,551	-29,820	$8,609
INBX	226,551	-29,820	$8,609
AMAZON COM INC	55,676	-39,624	$8,459
AMZN	55,676	-39,624	$8,459
ELI LILLY & CO	14,190	UNCH	$8,272
LLY	14,190	UNCH	$8,272
DAY ONE BIOPHARMACEUTICALS I	513,000	-17,000	$7,490
DAWN	513,000	-17,000	$7,490
TABOOLA.COM LTD	1,724,948	+1,724,948	$7,469
TBLA	1,724,948	+1,724,948	$7,469
ADVANCED MICRO DEVICES INC	50,387	+2,067	$7,428
AMD	50,387	+2,067	$7,428
PRAXIS PRECISION MEDICINES I	328,986	-4,521,331	$7,330
PRAX	328,986	-4,521,331	$7,330
ABBVIE INC	46,000	UNCH	$7,129
ABBV	46,000	UNCH	$7,129
WIX COM LTD	57,477	+57,477	$7,071
WIX	57,477	+57,477	$7,071
SOLAREDGE TECHNOLOGIES INC			$7,001
SEDG	48,000	+48,000	$4,493
Call	26,800	-26,700	$2,508
PHARVARIS N V	245,000	+245,000	$6,872
PHVS	245,000	+245,000	$6,872
INOZYME PHARMA INC	1,562,907	+328,000	$6,658
INZY	1,562,907	+328,000	$6,658
IMMATICS N.V	621,111	+3,938	$6,540
IMTX	621,111	+3,938	$6,540
MADRIGAL PHARMACEUTICALS INC	27,767	-23,100	$6,425
MDGL	27,767	-23,100	$6,425
MINERALYS THERAPEUTICS INC	743,591	+288,191	$6,395
MLYS	743,591	+288,191	$6,395
MERUS N V	230,333	-23,000	$6,334
MRUS	230,333	-23,000	$6,334
SPRINGWORKS THERAPEUTICS INC	170,270	-149,641	$6,215
SWTX	170,270	-149,641	$6,215
NOVARTIS AG	60,000	UNCH	$6,058
NVS	60,000	UNCH	$6,058
SENTINELONE INC	213,418	+213,418	$5,856
S	213,418	+213,418	$5,856
ROCKET PHARMACEUTICALS INC	190,783	-18,257	$5,718
RCKT	190,783	-18,257	$5,718
INCYTE CORP	89,556	+89,556	$5,623
INCY	89,556	+89,556	$5,623
GRACELL BIOTECHNOLOGIES INC	502,936	-1,028,561	$5,049
GRCL	502,936	-1,028,561	$5,049
SHL TELEMEDICINE LTD	632,456	+200	$5,044
SHLT	632,456	+200	$5,044
PALO ALTO NETWORKS INC	16,585	-12,174	$4,891
PANW	16,585	-12,174	$4,891
89BIO INC	408,674	+89,373	$4,565
ETNB	408,674	+89,373	$4,565
ALPINE IMMUNE SCIENCES INC	234,841	+54,841	$4,476
ALPN	234,841	+54,841	$4,476
ARROWHEAD PHARMACEUTICALS IN	144,899	+144,899	$4,434
ARWR	144,899	+144,899	$4,434
AMYLYX PHARMACEUTICALS INC			$4,175
AMLX	183,650	-10,000	$2,703
Call	100,000	+100,000	$1,472
VISTAGEN THERAPEUTICS INC	808,550	+708,550	$4,156
VTGN	808,550	+708,550	$4,156
JFROG LTD	109,905	+109,905	$3,804
FROG	109,905	+109,905	$3,804
PTC THERAPEUTICS INC	136,525	-81,934	$3,763
PTCT	136,525	-81,934	$3,763
UPWORK INC	252,784	+252,784	$3,759
UPWK	252,784	+252,784	$3,759
SAREPTA THERAPEUTICS INC			$3,751
Call	26,400	+26,400	$2,546
SRPT	12,500	-37,500	$1,205
GSK PLC	100,000	UNCH	$3,706
GSK	100,000	UNCH	$3,706
PLIANT THERAPEUTICS INC	193,554	+37,420	$3,505
PLRX	193,554	+37,420	$3,505
ENLIGHT RENEWABLE ENERGY LTD	169,280	+169,280	$3,240
ENLT	169,280	+169,280	$3,240
PFIZER INC	90,000	UNCH	$2,591
PFE	90,000	UNCH	$2,591
PROTHENA CORP PLC			$2,478
Call	68,200	+68,200	$2,478
WEREWOLF THERAPEUTICS INC	626,810	UNCH	$2,419
HOWL	626,810	UNCH	$2,419
PROMIS NEUROSCIENCES INC	1,834,042	UNCH	$2,109
PMN	1,834,042	UNCH	$2,109
ICL GROUP LTD	420,000	-50,000	$2,104
ICL	420,000	-50,000	$2,104
BROADCOM INC	1,800	+1,800	$2,009
AVGO	1,800	+1,800	$2,009
KEZAR LIFE SCIENCES INC	2,051,676	UNCH	$1,944
KZR	2,051,676	UNCH	$1,944
VIGIL NEUROSCIENCE INC	535,120	+535,120	$1,809
VIGL	535,120	+535,120	$1,809
RIGEL PHARMACEUTICALS INC	1,228,126	UNCH	$1,781
RIGL	1,228,126	UNCH	$1,781
CARGO THERAPEUTICS INC	75,000	+75,000	$1,736
CRGX	75,000	+75,000	$1,736
GILEAD SCIENCES INC	20,000	-20,000	$1,620
GILD	20,000	-20,000	$1,620
COGENT BIOSCIENCES INC	259,201	-160,799	$1,524
COGT	259,201	-160,799	$1,524
COMPUGEN LTD	769,239	-550,000	$1,523
CGEN	769,239	-550,000	$1,523
GOSSAMER BIO INC	1,338,090	-594,478	$1,221
GOSS	1,338,090	-594,478	$1,221
FIVE9 INC	15,000	+15,000	$1,180
FIVN	15,000	+15,000	$1,180
ORIC PHARMACEUTICALS INC	126,800	+126,800	$1,167
ORIC	126,800	+126,800	$1,167
REZOLUTE INC	996,710	UNCH	$989
RZLT	996,710	UNCH	$989
APOGEE THERAPEUTICS INC	30,000	UNCH	$838
APGE	30,000	UNCH	$838
CARTESIAN THERAPEUTICS INC	752,137	UNCH	$663
SELB	752,137	UNCH	$663
PRIME MEDICINE INC	73,980	+73,980	$655
PRME	73,980	+73,980	$655
JASPER THERAPEUTICS INC	713,063	-4,974,071	$563
JSPR	713,063	-4,974,071	$563
MEDIWOUND LTD	48,980	-59,553	$498
MDWD	48,980	-59,553	$498
ELEVATION ONCOLOGY INC	900,000	UNCH	$483
ELEV	900,000	UNCH	$483
VENTYX BIOSCIENCES INC	180,000	+180,000	$445
VTYX	180,000	+180,000	$445
MORPHIC HLDG INC	14,952	-75,048	$432
MORF	14,952	-75,048	$432
MONTE ROSA THERAPEUTICS INC	48,511	+48,511	$274
GLUE	48,511	+48,511	$274
REPLIMUNE GROUP INC	16,096	-168,920	$136
REPL	16,096	-168,920	$136
FREELINE THERAPEUTICS HLDGS	16,445	+16,445	$105
FRLN	16,445	+16,445	$105
ARBE ROBOTICS LTD	43,165	+43,165	$94
ARBE	43,165	+43,165	$94
PERSPECTIVE THERAPEUTICS INC	25,671	+25,671	$10
CATX	25,671	+25,671	$10
IMMATICS N.V	100,000	UNCH	<$1
IMTXW	100,000	UNCH	$0
SPDR SER TR (XBI)		-50,000	$-44,645
Put	500,000	+500,000	$44,645
CALLIDITAS THERAPEUTICS AB			$0 (exited)
CALT	0	-11,863	$0
CROWDSTRIKE HLDGS INC			$0 (exited)
CRWD	0	-15,000	$0
DISC MEDICINE INC			$0 (exited)
IRON	0	-111,398	$0
MIRUM PHARMACEUTICALS INC			$0 (exited)
MIRM	0	-114,284	$0
POINT BIOPHARMA GLOBAL INC			$0 (exited)
PNT	0	-952,642	$0
INVESCO QQQ TR			$0 (exited)
Put	0	-136,500	$0
UNIQURE NV			$0 (exited)
QURE	0	-148,734	$0
VERA THERAPEUTICS INC			$0 (exited)
VERA	0	-105,000	$0
XENON PHARMACEUTICALS INC			$0 (exited)
Put	0	-82,400	$0
XENE	0	-38,959	$0

See Summary: Sphera Funds Management LTD. Top Holdings
See Details: Top 10 Stocks Held By Sphera Funds Management LTD.

Entity	Shares/Amount Change	Position Value Change
Biggest New Positions
NVMI	+132,000	+$18,135
GLBE	+269,794	+$10,692
TBLA	+1,724,948	+$7,469
WIX	+57,477	+$7,071
PHVS	+245,000	+$6,872
S	+213,418	+$5,856
INCY	+89,556	+$5,623
ARWR	+144,899	+$4,434
FROG	+109,905	+$3,804
UPWK	+252,784	+$3,759

Entity	Shares/Amount Change	Position Value Change
Biggest Exited Positions
PNT	-952,642	-$6,354
IRON	-111,398	-$5,233
XBI	-50,000	-$3,651
MIRM	-114,284	-$3,611
CRWD	-15,000	-$2,511
VERA	-105,000	-$1,440
QURE	-148,734	-$998
CALT	-11,863	-$217
XENE	+43,441	+$1,484
QQQ	+136,500	+$48,904

Entity	Shares/Amount Change	Position Value Change
Biggest Position Increases
VTGN	+708,550	+$3,632
ATXS	+570,546	+$4,510
INZY	+328,000	+$1,471
MLYS	+288,191	+$2,064
CLDX	+151,344	+$9,401
AMLX	+90,000	+$629
ETNB	+89,373	-$365
TSEM	+58,726	+$4,591
ALPN	+54,841	+$2,415
PLRX	+37,420	+$798

Entity	Shares/Amount Change	Position Value Change
Biggest Position Decreases
ENPH	-20,833,100	-$8,490
JSPR	-4,974,071	-$3,418
PRAX	-4,521,331	-$964
TEVA	-1,860,700	-$18,079
GRCL	-1,028,561	+$638
GOSS	-594,478	-$388
XBI	-550,000	-$48,296
CGEN	-550,000	+$296
FUSN	-268,619	+$6,912

Sphera Funds Management LTD. Info

Size ($ in 1000's)
At 12/31/2023: $616,127
At 09/30/2023: $548,642

Combined Holding Report Includes:
SPHERA FUNDS MANAGEMENT LTD.
Sphera Global Healthcare Management LP
Sphera Global Healthcare GP Ltd.

Sphera Funds Management LTD. holdings changes, total fund size, and other information presented on HoldingsChannel.com was derived from Sphera Funds Management LTD. 13F filings. Link to 13F filings: SEC filings

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